Anthraquinones from Cassiae semen as thrombin inhibitors: in vitro and in silico studies.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.04.018
Abstract: Thrombin inhibitor therapy is one of the most effective therapeutic strategies for the prevention and treatment of cardiovascular and thrombotic diseases. Although several marketed direct thrombin inhibitors (DTIs) have been widely used in clinic, the… read more here.
Keywords: aurantio obtusin; thrombin inhibitors; cassiae semen; anthraquinones cassiae ... See more keywords
Biotransformation of Bioactive Metabolites in Cassiae Semen by Endogenous Enzymes and Probiotics.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c06864
Abstract: The present study evaluated the potential of endogenous enzymes and probiotics in transforming bioactive metabolites to reduce the purgative effect and improve the functional activity of Cassiae Semen and verified and revealed the biotransformation effect… read more here.
Keywords: effect; biotransformation; endogenous enzymes; cassiae semen ... See more keywords
Hepatoprotective effects of Cassiae Semen on mice with non-alcoholic fatty liver disease based on gut microbiota
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02883-8
Abstract: Cassiae Semen (CS), the seeds of Cassia obtusifolia L. and C. tora L, have a long medicinal history in China, with suggestions for it to relieve constipation and exert hepatoprotective effects. However, the underlying mechanisms… read more here.
Keywords: gut microbiota; cassiae semen; hepatoprotective effects; non alcoholic ... See more keywords
Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience Reports"
DOI: 10.1042/bsr20221375
Abstract: Abstract Background: Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, the mechanism of action of CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny. Objective: The… read more here.
Keywords: pharmacology; regulating lipid; lipid metabolism; semen regulating ... See more keywords
Protective effects of Forsythiae fructus and Cassiae semen water extract against memory deficits through the gut-microbiome-brain axis in an Alzheimer’s disease model
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2025860
Abstract: Abstract Context Fruits of Forsythia suspensa Vahl (Oleaceae) and seeds of Cassia obtusifolia Linne (Caesalpinaceae) have been used to treat inflammation in Asia. Objective We examined the alleviation of memory function in Alzheimer's disease (AD)… read more here.
Keywords: cassiae semen; memory; semen water; forsythiae fructus ... See more keywords
Network Pharmacology-Based Strategy to Reveal the Mechanism of Cassiae Semen against Cataracts
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/5654120
Abstract: Cassiae semen (CS) is one of the most well-known herbs used in the treatment of cataracts in China. However, the potential mechanisms of its anticataract effects have not been fully explored. In this study, network… read more here.
Keywords: pharmacology; cassiae semen; network pharmacology; mechanism ... See more keywords
Inhibitory effects of cassiae semen extract on the formation of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in model system
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2024.1407007
Abstract: Introduction 2-Amino-1-methyl-6-phenylimidazole [4,5-b] pyridine (PhIP), a heterocyclic amine (HAA), is found in meat products heated at high temperatures. However, PhIP is a mutagenic and potential carcinogenic compound. Cassiae semen, a type of medicine and food… read more here.
Keywords: system; phip; model; cassiae semen ... See more keywords
Cassiae semen extract ameliorates hyperlipidemia in rats by modulating lipid metabolism and FcγR-mediated immune regulation
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1546119
Abstract: Introduction: Cassiae Semen Extract (CSE) shows promise in treating hyperlipidemia, although its underlying mechanisms are not yet fully understood. This study aimed to investigate the effects of CSE on hyperlipidemia in rats and explore the… read more here.
Keywords: lipid metabolism; hyperlipidemia rats; cassiae semen; semen extract ... See more keywords