Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq.
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DOI: 10.1016/j.stem.2021.02.002
Abstract: Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases. Here we describe chromosomal aberrations analysis by single targeted linker-mediated PCR sequencing… read more here.
Keywords: stem cells; cast seq; target; gene edited ... See more keywords