Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF‐κB pathway and ROS signaling
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DOI: 10.1002/ptr.6108
Abstract: Casticin, a compound purified from the Chinese herb Viticis Fructus, has been proven effective in preventing tumor progression in previous studies. Ulcerative colitis (UC) is a common inflammatory bowel disease that affects millions of people… read more here.
Keywords: dss induced; colitis mice; casticin; ulcerative colitis ... See more keywords
Casticin protects against IL‐1&bgr;‐induced inflammation in human osteoarthritis chondrocytes
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.10.051
Abstract: Abstract Casticin, an active compound isolated from Vitex rotundifolia L., was reported to possess anti‐inflammatory activity. However, the effect of casticin on inflammatory response in human osteoarthritis (OA) chondrocytes remains unclear. In the current study,… read more here.
Keywords: bgr; casticin; human osteoarthritis; bgr induced ... See more keywords
Casticin Induces DNA Damage and Impairs DNA Repair in Human Bladder Cancer TSGH-8301 Cells
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DOI: 10.21873/anticanres.13291
Abstract: Background/Aim: Casticin shows anti-cancer effects in many types of cancer. However, there is no information regarding its role in DNA damage in human bladder cancer. The aim of this study was to investigate the effects… read more here.
Keywords: dna damage; human bladder; microscopy; casticin ... See more keywords
Protective Effects of Casticin From Vitex trifolia Alleviate Eosinophilic Airway Inflammation and Oxidative Stress in a Murine Asthma Model
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DOI: 10.3389/fphar.2018.00635
Abstract: Casticin has been isolated from Vitex trifolia and found to have anti-inflammatory and anti-tumor properties. We also previously discovered that casticin can reduce pro-inflammatory cytokines and ICAM-1 expression in inflammatory pulmonary epithelial cells. In the… read more here.
Keywords: airway inflammation; casticin; vitex trifolia; oxidative stress ... See more keywords
Casticin Impacts Key Signaling Pathways in Colorectal Cancer Cells Leading to Cell Death with Therapeutic Implications
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DOI: 10.3390/genes13050815
Abstract: Colorectal cancer is the third most frequently encountered cancer worldwide. While current chemotherapeutics help to manage the disease to some extent, they have eluded achieving complete remission and are limited by their severe side effects.… read more here.
Keywords: cell death; cell; cancer; cancer cells ... See more keywords