Survival by first‐line therapy and prognostic group among men with metastatic castration‐resistant prostate cancer
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DOI: 10.1002/cam4.7334
Abstract: Metastatic castration‐resistant prostate cancer (mCRPC) is a heterogeneous disease with prognoses varying from months to years at time of castration‐resistant diagnosis. Optimal first‐line therapy for those with different prognoses is unknown. read more here.
Keywords: prostate cancer; castration resistant; castration; metastatic castration ... See more keywords
Sox2 Expression Marks Castration‐Resistant Progenitor Cells in the Adult Murine Prostate
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DOI: 10.1002/stem.2987
Abstract: Identification of defined epithelial cell populations with progenitor properties is critical for understanding prostatic development and disease. Here, we demonstrate that Sox2 expression is enriched in the epithelial cells of the proximal prostate adjacent to… read more here.
Keywords: prostate; sox2 expression; castration; sox2 ... See more keywords
Administration of meloxicam before rather than after castration on eating, defecation and pain indicators in pet rabbits (Oryctolagus cuniculus)
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DOI: 10.1002/vms3.1354
Abstract: Abstract Background Rabbits are extremely sensitive to pain. There is evidence on whether non‐steroidal anti‐inflammatory medication should be administered before or after surgery in rabbits. Objectives In this study, we compared the pain scores and… read more here.
Keywords: surgery; pain; castration; administration meloxicam ... See more keywords
M0CRPC overview of management options
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DOI: 10.1007/s00345-019-02997-z
Abstract: Though prostate cancer usually responds to androgen deprivation therapy (ADT) in the beginning, the majority of prostate cancers will develop castration resistance over time. The androgen receptor (AR) pathway is often found to be activated… read more here.
Keywords: m0crpc overview; management options; urology; castration ... See more keywords
Regression of castration-resistant prostate cancer by a novel compound QW07 targeting androgen receptor N-terminal domain
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-020-09511-x
Abstract: Androgen deprivation therapy (ADT) via surgical or chemical castration frequently fails to halt lethal castration-resistant prostate cancer (CRPC), which is induced by multiple mechanisms involving constitutive androgen receptor (AR) splice variants, AR mutation, and/or de… read more here.
Keywords: qw07; androgen; prostate cancer; compound ... See more keywords
Selection and monitoring of patients with metastatic castration-resistant prostate cancer for treatment with radium-223
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DOI: 10.1007/s12094-017-1785-0
Abstract: Despite the improvement provided by androgenic suppression in the treatment of prostate cancer, most of tumors develop resistance to castration. However, new therapies have demonstrated an increase in patient survival such as radium-223 (Ra-223), an… read more here.
Keywords: castration; treatment; radium 223; prostate cancer ... See more keywords
Economic Outcomes in Patients with Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer Treated with Enzalutamide or Abiraterone Acetate Plus Prednisone
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DOI: 10.1007/s12325-020-01260-x
Abstract: Introduction Prostate cancer (PC) is the second leading cause of cancer death among US men and accounts for considerable healthcare expenditures. We evaluated economic outcomes in men with chemotherapy-naïve metastatic castration-resistant PC (mCRPC) treated with… read more here.
Keywords: cause; enzalutamide abiraterone; treated enzalutamide; castration ... See more keywords
Comparison of Real-World Outcomes between Patients with BRCA1/2-Positive and Homologous Recombination Repair-Negative Metastatic Castration-Sensitive Prostate Cancer
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DOI: 10.1007/s12325-025-03270-z
Abstract: This real-world study compared time-to-next-treatment (TTNT), time-to-castration resistance (TTCR), and overall survival between patients with BRCA1/2-positive (BRCA+) and homologous recombination repair-negative (HRR–) metastatic castration-sensitive prostate cancer (mCSPC). Patients who received a genetic test and initiated… read more here.
Keywords: treatment; real world; castration; brca hrr ... See more keywords
Metalloproteinase 11, potential marker and molecular target in advanced and castration-resistant prostate cancer. Culture study of peritumoral fibroblasts.
Sign Up to like & getrecommendations! Published in 2017 at "Actas urologicas espanolas"
DOI: 10.1016/j.acuro.2016.12.001
Abstract: OBJECTIVE To analyze the expression of metalloprotein 11 (MMP11) in cultured fibroblasts obtained from human prostate tumors with different clinical and pathological characteristics. MATERIAL AND METHODS For this study we analyzed samples of transrectal prostate… read more here.
Keywords: prostate; metalloproteinase potential; expression; castration ... See more keywords
Systemic treatment for metastatic prostate cancer
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DOI: 10.1016/j.ajur.2019.02.002
Abstract: The management of metastatic prostate cancer (mPCa) has changed over the past ten years. Several new drugs have been approved with significant overall survival benefits in metastatic castration resistant prostate cancer (PCa) including chemotherapy (docetaxel,… read more here.
Keywords: prostate; metastatic prostate; treatment; prostate cancer ... See more keywords
GPER1 in sand rat epididymis: Effects of seasonal variations, castration and efferent ducts ligation.
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DOI: 10.1016/j.anireprosci.2017.06.012
Abstract: Estrogen plays a crucial role in regulating epididymal function and development. Estrogen signaling is mediated via two main receptors essentially involved in the genomic regulating pathway: ERα and ERβ. Recent studies revealed the contribution of… read more here.
Keywords: sand; efferent ducts; estrogen; gper1 ... See more keywords