Abstract B018: Loss of androgen receptor-mediated repression leads to EphA2 overexpression that promotes cellular dedifferentiation and castration resistance of prostate cancer through noncanonical signaling
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DOI: 10.1158/1538-7445.prca2023-b018
Abstract: As a member of Eph subfamily receptor tyrosine kinases, EphA2 has been extensively studied in cancer. It is frequently overexpressed in many different types of human cancer, which is often correlated with tumor progression. We… read more here.
Keywords: prostate cancer; castration resistance; noncanonical signaling; receptor ... See more keywords
Cancer Stemness/Epithelial–Mesenchymal Transition Axis Influences Metastasis and Castration Resistance in Prostate Cancer: Potential Therapeutic Target
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DOI: 10.3390/ijms232314917
Abstract: Prostate cancer (PCa) is a leading cause of cancer death in men, worldwide. Mortality is highly related to metastasis and hormone resistance, but the molecular underlying mechanisms are poorly understood. We have studied the presence… read more here.
Keywords: metastasis; metastasis castration; cancer; castration resistance ... See more keywords