A broken heart can mend
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0259-9
Abstract: CasX was initially identified from groundwater samples via metagenomics analysis. Although it contained no similarity to other CRISPR–Cas9 enzymes, Liu et al. investigated whether CasX might act as a genome-editing enzyme. Biochemical and structural analyses… read more here.
Keywords: genome editing; dna; broken heart; casx ... See more keywords
Abstract 4146303: A Single-Dose of a Novel CasX-Editor Lowers APOC3 Levels In Vivo
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4146303
Abstract: Background: Apolipoprotein C-III (APOC3) is a key regulator of lipid metabolism that inhibits the catabolism and clearance of triglyceride (TG)-rich lipoproteins in the blood. Loss-of-function APOC3 variants are associated with significantly lower TG levels and… read more here.
Keywords: single dose; 1400 lead; stx 1400; lead molecules ... See more keywords