CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism
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DOI: 10.1126/sciadv.aax2887
Abstract: CATACOMB is a catalytic antagonist PRC2 subunit whose expression is induced upon DNA demethylation. Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the NuA4… read more here.
Keywords: methylation; polycomb repressive; repressive complex; prc2 ... See more keywords