Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0873-9
Abstract: Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa, can produce… read more here.
Keywords: inhibiting nox4; inflammation; stress; catalpol inhibiting ... See more keywords
Therapeutic effect of catalpol on type 2 diabetic mice induced by STZ and high-fat diet and its possible mechanism
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Diabetes in Developing Countries"
DOI: 10.1007/s13410-018-0685-3
Abstract: To explore the therapeutic effect and possible mechanism of catalpol on type 2 diabetic mice. Twenty-four C57/BL6 male mice were randomly divided into four groups—normal control group (CON, n = 6), diabetic model group (DM, n = 6), the… read more here.
Keywords: insulin; mechanism; group; mice ... See more keywords
A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG‐mediated myogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.08.028
Abstract: Aims: Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid glycoside, has been shown to exert a hypoglycaemic effect by improvement of insulin… read more here.
Keywords: mechanism; insulin sensitivity; myogenesis; myog ... See more keywords
Catalpol relieved angiotensin II-induced blood–brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2142801
Abstract: Abstract Context Catalpol is a major bioactive constituent of Rehmannia glutinosa Libosch (Scrophulariaceae), a traditional Chinese medicine, which is widely used in multiple diseases, including hypertension. Objectives To explore whether catalpol protects against angiotensin II… read more here.
Keywords: catalpol relieved; blood brain; brain barrier; brain ... See more keywords
Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Bioengineered"
DOI: 10.1080/21655979.2020.1863015
Abstract: Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of worldwide population, and causing long-term troubles to the patients. Therefore, it is urgent to develop safe and effective therapeutic drugs. Catalpol is a… read more here.
Keywords: mapks signaling; psoriasis; catalpol; psoriasis like ... See more keywords
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/2876350
Abstract: Catalpol, an iridoid glucoside, has been found present in large quantities in the root of Rehmannia glutinosa L. and showed a strong antioxidant capacity in the previous study. In the present work, the protective effect… read more here.
Keywords: tert pathway; dna damage; pgc tert; pgc ... See more keywords
Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5668226
Abstract: Random-pattern skin flap necrosis limits its application in the clinic. It is still a challenge for plastic surgeons. Catalpol is an effective ingredient extracted from Rehmannia glutinosa, which is reported to promote angiogenesis and protect… read more here.
Keywords: skin; flap; catalpol; sirt1 ... See more keywords
Catalpol protects mouse ATDC5 chondrocytes against interleukin-1β-induced catabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-575
Abstract: Catalpol is a natural product with promising anti-inflammatory effects, however, its effects on chondrocytes and osteoarthritis (OA) have not been well investigated. OA is a painful and debilitating joint disease that affects people worldwide. Traditional… read more here.
Keywords: mouse atdc5; protects mouse; atdc5 chondrocytes; catalpol protects ... See more keywords
Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Κb Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Public Health"
DOI: 10.18502/ijph.v52i4.12440
Abstract: Background: We aimed to explore catalpol and NF-k. The role of antidepressant and anti-inflammatory effects of b inhibitor in depression induced by chronic unpredictable mild stress (CUMS). Methods: Under the guidance of Qiqihar Medical University,… read more here.
Keywords: depression; level; model; tlr4 mapk ... See more keywords
Effect and Mechanism of Catalpol on Remyelination via Regulation of the NOTCH1 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.628209
Abstract: Promoting the differentiation of oligodendrocyte precursor cells (OPCs) is important for fostering remyelination in multiple sclerosis. Catalpol has the potential to promote remyelination and exert neuroprotective effects, but its specific mechanism is still unclear. Recent… read more here.
Keywords: mechanism; remyelination; notch1 signaling; signaling pathway ... See more keywords
Catalpol in Diabetes and its Complications: A Review of Pharmacology, Pharmacokinetics, and Safety
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24183302
Abstract: This review aimed to provide a general view of catalpol in protection against diabetes and diabetic complications, as well as its pharmacokinetics and safety concerns. The following databases were consulted with the retrieval of more… read more here.
Keywords: pharmacology; catalpol diabetes; pharmacokinetics safety; diabetic complications ... See more keywords