Enantioselective synthesis of (R)-Cinacalcet via cobalt-catalysed asymmetric Negishi cross-coupling.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23085
Abstract: A novel enantioselective synthesis of (R)-cinacalcet with 99% enantiomeric excesses (ee) has been achieved. The main strategies of the approach include a gram-scale cobalt-catalysed asymmetric cross-coupling of racemic ester with arylzinc reagent, Hoffman-type rearrangement of… read more here.
Keywords: catalysed asymmetric; cobalt catalysed; synthesis cinacalcet; cross coupling ... See more keywords
CuII-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with a chiral ferrocene-derived P,N-ligand
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.05.044
Abstract: A ferrocene-derived P,N-heterodonor ligand was effectively used in a Cu(OAc)2·H2O-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with maleate derivatives, affording cycloadducts with high yields (up to 96%), diastereoselectivities (>99 dr), and enantioselectivities (up to 99%… read more here.
Keywords: asymmetric dipolar; azomethine ylides; catalysed asymmetric; ferrocene derived ... See more keywords
Photoinduced copper-catalysed asymmetric amidation via ligand cooperativity.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03730-w
Abstract: The substitution of an alkyl electrophile by a nucleophile is a foundational reaction in organic chemistry that enables the efficient and convergent synthesis of organic molecules. Whereas substantial progress has been reported in recent years… read more here.
Keywords: catalysed asymmetric; copper; asymmetric amidation; substitution ... See more keywords
Lewis acid catalysed asymmetric cascade reaction of cyclopropyl ketones: concise synthesis of pyrrolobenzothiazoles.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05667g
Abstract: Utilizing the C4 reactive site of cyclopropyl ketones and a chiral N,N'-dioxide-scandium(iii) complex as a catalyst, a concise ring-opening/cyclization/thio-Michael cascade method was developed for the synthesis of chiral benzothiazole derivatives from a simple 2-aminothiophenol material.… read more here.
Keywords: lewis acid; catalysed asymmetric; cyclopropyl; asymmetric cascade ... See more keywords
Facile access to chiral γ-butyrolactones via rhodium-catalysed asymmetric hydrogenation of γ-butenolides and γ-hydroxybutenolides
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00491k
Abstract: The highly efficient Rh/ZhaoPhos-catalysed asymmetric hydrogenation of γ-butenolides and γ-hydroxybutenolides was successfully developed. This protocol provides an efficient and practical approach to the synthesis of various chiral γ-butyrolactones, which are synthetically valuable building blocks of… read more here.
Keywords: butenolides hydroxybutenolides; asymmetric hydrogenation; chiral butyrolactones; catalysed asymmetric ... See more keywords
Mechanism of formation of active catalytic species in nickel-catalysed asymmetric hydrogenation
Sign Up to like & getrecommendations! Published in 2025 at "Mendeleev Communications"
DOI: 10.71267/mencom.7818
Abstract: Initial stages of two representative Ni-catalysed asymmetric hydrogenations were investigated computationally featuring the formation of the active catalytic species [R,R-BenzP*NiH]+ from R,R-BenzP*Ni(OAc)2 and [S,S-Ph-BPENiH]+ from S,S-Ph-BPENi(OAc)2. Among several computed pathways the most feasible is dissociation… read more here.
Keywords: sup; formation active; active catalytic; sub ... See more keywords