Lewis Base Catalysis Enables the Activation of Alcohols by means of Chloroformates as Phosgene Substitutes
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DOI: 10.1002/cctc.202001175
Abstract: Nucleophilic substitutions (SN) are typically promoted by acid chlorides as sacrificial reagents to improve the thermodynamic driving force and lower kinetic barriers. However, the cheapest acid chloride phosgene (COCl2) is a highly toxic gas. Against… read more here.
Keywords: catalysis enables; enables activation; base catalysis; lewis base ... See more keywords
Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes
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DOI: 10.1021/acs.orglett.2c00355
Abstract: Oxetanes are valuable building blocks due to their well-explored propensity to undergo ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, we present a bioinspired cobalt-catalysis-based strategy to… read more here.
Keywords: catalysis enables; cobalt catalysis; nucleophilic radicals; bioinspired cobalt ... See more keywords
Photoredox Catalysis Enables Access to N-Functionalized 2,1-Borazaronaphthalenes.
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DOI: 10.1021/acs.orglett.9b00884
Abstract: The synthesis and utilization of a class of 2,1-borazaronaphthyltrifluoroborate reagents that provide a general solution to the challenge of N-functionalization of the 2,1-borazaronaphthalene core is described. By adorning the nitrogen of this core with a… read more here.
Keywords: functionalized borazaronaphthalenes; enables access; photoredox catalysis; access functionalized ... See more keywords
Ligand Relay Catalysis Enables Asymmetric Migratory Reductive Acylation of Olefins or Alkyl Halides.
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DOI: 10.1021/jacs.2c10785
Abstract: Design of ligands in transition-metal catalyzed reactions is challenging, especially in asymmetric transformations. With each step in the catalytic cycle promoted by its privileged ligand and different steps well-connected by dynamic ligand exchange, synergistic combination… read more here.
Keywords: enables asymmetric; catalysis enables; alkyl halides; acylation ... See more keywords