Catalyst-controlled diastereoselective ring-opening formal [3+2]-cycloadditions of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines
Sign Up to like & getrecommendations! Published in 2020 at "Science China Chemistry"
DOI: 10.1007/s11426-019-9760-7
Abstract: A diastereoselectivity-controllable formal [3+2]-cycloaddition of arylvinyl oxirane 2,2-diesters with cyclic N-sulfonyl imines is developed, affording the corresponding tricyclic oxazolidine derivatives in moderate to excellent yields with excellent diastereoselectivities in the presence of palladium(0) or scandium(III)… read more here.
Keywords: catalyst controlled; sulfonyl imines; oxirane diesters; cyclic sulfonyl ... See more keywords
Computational study on the catalyst-controlled synthesis of C2-substituted quinolines through the annulation of 2-vinylanilines and alkynoates
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2019.06.021
Abstract: Abstract Density functional theory (DFT) calculations were employed to study the reaction mechanisms of the synthesis of C-2 functionalized indole/quinoline catalyzed by TfOH/Pd(OAc) 2 . Our calculated results verify the experimental phenomena that the selectivity… read more here.
Keywords: synthesis; catalyst; study catalyst; catalyst controlled ... See more keywords
Catalyst-Controlled Site-Selective Bond Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.6b00546
Abstract: One ultimate goal of synthetic chemistry is to install or manipulate any functional group at any position of a molecule. This Account discusses the potential and possible approaches to use catalysis to enable a reaction… read more here.
Keywords: catalyst controlled; controlled site; site selective; chemistry ... See more keywords
Catalyst-Controlled Divergent Reactions of 2,3-Disubstituted Indoles with Propargylic Alcohols: Synthesis of 3H-Benzo[b]azepines and Axially Chiral Tetrasubstituted Allenes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02642
Abstract: Catalyst-controlled divergent reactions of 2,3-disubstituted indoles with propargylic alcohols were developed for the first time. In the presence of TsOH or B(C6F5)3 as catalyst, 2,3-disubstituted indoles reacted smoothly with 3-alkynyl-3-hydroxyisoindolinones to afford 3H-benzo[b]azepines by selective… read more here.
Keywords: controlled divergent; catalyst; disubstituted indoles; catalyst controlled ... See more keywords
Catalyst-Controlled Chemodivergent Reactivity of Vinyl Cyclopropanes: A Selective Approach toward Indoles and Aniline Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03680
Abstract: Herein, we disclose a catalyst-controlled chemodivergent approach to access C2-substituted indoles and diverse aniline derivatives with good chemo- and stereoselectivity by employing vinylcyclopropanes (VCPs) as coupling partners via a tandem C-H/C-C activation/annulation strategy. The key… read more here.
Keywords: chemodivergent reactivity; aniline derivatives; controlled chemodivergent; catalyst controlled ... See more keywords
A General Catalyst Controlled Route to Prostaglandin F2α
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c03718
Abstract: We report a general, catalyst-controlled route to prostaglandin F2α and its analogues. The approach uses a Rh-catalyzed dynamic kinetic asymmetric Suzuki–Miyaura coupling reaction between a racemic bicyclic allyl chloride and alkenyl boronic esters bearing chiral… read more here.
Keywords: controlled route; catalyst controlled; route prostaglandin; general catalyst ... See more keywords
Catalyst-Controlled Diastereoselective Synthesis of Bridged [3.3.1] Bis(Indolyl)-Oxanes and Oxepanes via Desymmetrization of Bis(Indolyl)-Cyclohexadienones.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00834
Abstract: A catalyst-controlled divergent synthesis of bridged [3.3.1] bis(indolyl)-oxanes and cis-[6.7] fused bis(indolyl) oxepanes via diastereoselective desymmetrization of bis(indolyl)-cyclohexadienones is presented for the first time. The reaction is highly atom- and step-economic, furnishing sp3-rich functionalized bis(indolyl)… read more here.
Keywords: catalyst controlled; synthesis bridged; bis; bis indolyl ... See more keywords
Catalyst-Controlled Regioselective Acylation of β-Ketoesters with α-Diazo Ketones Induced by Visible Light.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03189
Abstract: A catalyst-controlled acylation reaction of β-ketoesters was developed for the first time by combining visible-light photoactivation with Lewis acid or base catalysis. By employing a NiCl2·glyme complex with a bis(oxazoline) ligand as the Lewis acid… read more here.
Keywords: catalyst controlled; regioselective acylation; visible light; acylation ... See more keywords
Catalyst-Controlled Stereodivergent Synthesis of Atropisomeric Multiaxis Systems
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DOI: 10.1021/acscentsci.8b00204
Abstract: Molecular scaffolds with multiple rotationally restricted bonds allow a precise spatial positioning of functional groups. However, their synthesis requires methods addressing the configuration of each stereogenic axis. We report here a catalyst-stereocontrolled synthesis of atropisomeric… read more here.
Keywords: synthesis atropisomeric; multiaxis systems; atropisomeric multiaxis; catalyst controlled ... See more keywords
Studies of Catalyst-Controlled Regioselective Acetalization and Its Application to Single-Pot Synthesis of Differentially Protected Saccharides.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c08448
Abstract: This article describes studies on the regioselective acetal protection of monosaccharide-based diols using chiral phosphoric acids (CPAs) and their immobilized polymeric variants, (R)-Ad-TRIP-PS and (S)-SPINOL-PS, as the catalysts. These catalyst-controlled regioselective acetalizations were found to… read more here.
Keywords: catalyst controlled; single pot; differentially protected; studies catalyst ... See more keywords
Origins of Catalyst-Controlled Selectivity in Ag-Catalyzed Regiodivergent C-H Amination.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12111
Abstract: Ag-catalyzed nitrene transfer (NT) converts C-H bonds into valuable C-N bonds. These reactions offer a promising strategy for catalyst-controlled regiodivergent functionalization of different types of reactive C-H bonds, as the regioselectivity is tunable by varying… read more here.
Keywords: regiodivergent amination; origins catalyst; catalyst controlled; amination ... See more keywords