Catalytic Asymmetric Huisgen Alkyne–Azide Cycloaddition of Bisalkynes by Copper(I) Nanoparticles
Sign Up to like & getrecommendations! Published in 2018 at "ChemCatChem"
DOI: 10.1002/cctc.201701336
Abstract: The use of chiral ligands to tune the reactivity and enantioselectivity of transition‐metal catalyst for asymmetric transformations is a central challenge in synthetic organic chemistry. In this manuscript, chiral P‐ligand (Tao‐Phos)‐assisted Cu2O‐nanoparticles‐catalyzed asymmetric azide–alkyne Huisgen… read more here.
Keywords: cycloaddition; huisgen; huisgen alkyne; copper ... See more keywords
Catalytic Asymmetric Synthesis of Chiral Dihydrobenzofurans through a Formal [4+1] Annulation Reaction of Sulfur Ylides and In Situ Generated ortho‐Quinone Methides
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601186
Abstract: The first example of a catalytic asymmetric formal [4+1] annulation reaction between sulfur ylides and in situ generated ortho-quinone methides (o-QMs) is reported in this work. A C2-symmetric chiral urea was identified to be the… read more here.
Keywords: sulfur ylides; reaction sulfur; formal annulation; catalytic asymmetric ... See more keywords
Catalytic Asymmetric Synthesis of Spiropyrazolones and their Application in Medicinal Chemistry.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical record"
DOI: 10.1002/tcr.201800199
Abstract: Chiral spiropyrazolones are unique frameworks widely found in a large family of medicinally relevant compounds with various biological activities. Substantial research efforts have been invested toward stereoselectively by constructing spiro-cyclic structures. Over the past years,… read more here.
Keywords: chemistry; asymmetric synthesis; spiropyrazolones application; catalytic asymmetric ... See more keywords
Catalytic Asymmetric Radical Diamination of Alkenes
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DOI: 10.1016/j.chempr.2017.10.008
Abstract: Summary Catalytic asymmetric diamination of alkenes is a highly attractive method for creating chiral vicinal diamines, which are ubiquitous in biologically active molecules and versatile ligands as well as organocatalysts. We report the use of… read more here.
Keywords: diamination; asymmetric radical; diamination alkenes; reaction ... See more keywords
Removing the Mask in Catalytic Asymmetric Diamination of Alkenes
Sign Up to like & getrecommendations! Published in 2017 at "Chem"
DOI: 10.1016/j.chempr.2017.11.012
Abstract: In this issue of Chem , Liu and co-workers report an extremely general and mild radical diamination protocol that permits the asymmetric synthesis of vicinal diamines in a highly enantioselective manner under a copper(I)/chiral phosphate… read more here.
Keywords: diamination; removing mask; asymmetric diamination; mask catalytic ... See more keywords
Catalytic Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Umpolung Cross-Mannich Reaction of Cyclic Ketimines.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01578
Abstract: A catalytic asymmetric umpolung cross-Mannich reaction of cyclic ketimines is realized. This protocol provides an efficient methodology for the facile synthesis of chiral vicinal tetrasubstituted diamines in high yields with excellent chemo-, regio-, diastereo-, and… read more here.
Keywords: mannich reaction; reaction cyclic; cyclic ketimines; umpolung cross ... See more keywords
Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper-Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01594
Abstract: A catalytic asymmetric decarboxylative [3 + 2] annulation via indolyl copper-allenylidene amphiphilic intermediates has been developed. This protocol offers a straightforward method for the synthesis of biologically important pyrrolo[1,2-a]indoles bearing contiguous quaternary and tertiary stereogenic… read more here.
Keywords: pyrrolo; pyrrolo indoles; annulation via; indolyl copper ... See more keywords
Catalytic Asymmetric Addition Reactions of Formaldehyde N,N-Dialkylhydrazone to Synthesize Chiral Nitrile Derivatives.
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DOI: 10.1021/acs.orglett.0c01857
Abstract: A number of nitrile-containing chiral molecules were synthesized via asymmetric nucleophilic addition of formaldehyde N,N-dialkylhydrazone as the nitrile equivalent. Chiral N,N'-dioxide/metal salt complexes enabled the asymmetric addition reactions to both isatin-derived imines and α,β-unsaturated ketones,… read more here.
Keywords: formaldehyde dialkylhydrazone; addition; asymmetric addition; addition reactions ... See more keywords
Catalytic Asymmetric Construction of a 1,2,4-Benzotriazepine Skeleton via Diastereo- and Enantioselective Decarboxylative [4 + 3] Cyclization.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00073
Abstract: We have developed a protocol for palladium-catalyzed decarboxylative [4 + 3] cycloaddition reactions between 4-vinyl benzoxazinanones and azomethine imines to generate moderate to good yields of structurally diverse 1,2,4-benzotriazepines bearing two stereogenic centers with good… read more here.
Keywords: asymmetric construction; skeleton; construction benzotriazepine; benzotriazepine skeleton ... See more keywords
An Asymmetric Synthesis of (+)-Isostrychnine Based on Catalytic Asymmetric Tandem Double Michael Addition.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01828
Abstract: Herein, a concise asymmetric synthesis of (+)-isostrychnine is achieved in nine longest-linear steps with a 16% overall yield. The key features of this synthesis include the catalytic asymmetric tandem double Michael addition of a tryptamine-derived… read more here.
Keywords: tandem double; asymmetric tandem; synthesis isostrychnine; double michael ... See more keywords
Catalytic Asymmetric [3 + 2] Annulation of Hantzsch Esters with Racemic N-Sulfonylaziridines.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02931
Abstract: Hantzsch esters (HEs) served as two-carbon partners in a copper(I)-catalyzed enantioselective [3 + 2] annulation with racemic 2-(hetero)aryl-N-sulfonyl aziridines via kinetic resolution to provide pyrrolo[2,3-b]tetrahydropyridines containing multiple contiguous stereogenic centers including all-carbon quaternary centers in… read more here.
Keywords: annulation hantzsch; asymmetric annulation; hantzsch esters; hantzsch ... See more keywords