Catalytic Atroposelective Synthesis of Axially Chiral Heterobiaryl Oxime Ethers via the One-Step Dynamic Kinetic Condensation Reaction.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c00479
Abstract: The catalytic atroposelective synthesis of axially chiral heterobiaryls was first developed through the direct one-step dynamic kinetic condensation reaction with the simple transformation of the C═O bond to the C═N bond, delivering a series of… read more here.
Keywords: axially chiral; atroposelective synthesis; one step; synthesis axially ... See more keywords
Catalytic Atroposelective Friedel-Crafts Alkylation to Access Axially Chiral C2-Arylindoles via Dynamic Kinetic Resolutions
Sign Up to like & getrecommendations! Published in 2025 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo01611d
Abstract: Indole-based atropisomers have emerged as an important backbone in drug discovery and novel catalyst/ligand design. However, the development of asymmetric synthesis of axially chiral 2-arylindoles is sluggish due to the... read more here.
Keywords: friedel crafts; axially chiral; atroposelective friedel; crafts alkylation ... See more keywords