Bio-Inspired Electrochemical Detection of Nitric Oxide Promoted by Coordinating the Histamine-Iron Phthalocyanine Catalytic Center on Microelectrode.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00299
Abstract: Biomimetic structures to fabricate bioelectronic interfaces that allow sensors to electrically communicate with electrodes have potential applications in the development of biosensors. Herein, inspired by the structure feature of nitric oxide (NO) sensory protein, we… read more here.
Keywords: catalytic center; bio inspired; nitric oxide; iron phthalocyanine ... See more keywords
Mapping the Substrate Recognition Pathway in Cytochrome P450.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b10840
Abstract: Cytochrome P450s are ubiquitous metalloenzymes involved in the metabolism and detoxification of foreign components via catalysis of the hydroxylation reactions of a vast array of organic substrates. However, the mechanism underlying the pharmaceutically critical process… read more here.
Keywords: cytochrome p450; catalytic center; substrate; substrate recognition ... See more keywords
Characterization of tomato protein kinases embedding guanylate cyclase catalytic center motif
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61000-7
Abstract: Guanylate cyclases (GCs) are enzymes that catalyze the reaction to produce cyclic GMP (cGMP), a key signaling molecule in eukaryotes. Nevertheless, systemic identification and functional analysis of GCs in crop plant species have not yet… read more here.
Keywords: catalytic center; kinases embedding; center motif; protein kinases ... See more keywords
Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1308
Abstract: Abstract Intracellular levels of reactive oxygen species (ROS) increase as a consequence of oxidative stress and represent a major source of damage to biomolecules. Due to its high cellular abundance RNA is more frequently the… read more here.
Keywords: catalytic center; rna; stress; damage ... See more keywords
Mechanism of 5ʹ splice site transfer for human spliceosome activation
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aax3289
Abstract: Creation of the splicing catalytic center The catalytic center of the fully assembled, precatalytic pre–B spliceosome is not yet formed, even though all the pieces are present in this complex. Charenton et al. solved the… read more here.
Keywords: catalytic center; human spliceosome; splice site; site ... See more keywords
Preparation and characterization of the antibody recognizing AMACR inside its catalytic center.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4220
Abstract: Alpha-methylacyl-CoA racemase (AMACR) catalyzes the β-oxidation of fatty acids and is overexpressed in carcinomas in various organs, while its inactivation results in the inhibition of cancer growth. In the present study, we prepared and characterized… read more here.
Keywords: catalytic center; antibody; characterization antibody; preparation characterization ... See more keywords