Domain function and predicted structure of three heterodimeric endonuclease subunits of RNA editing catalytic complexes in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac753
Abstract: Abstract Each of the three similar RNA Editing Catalytic Complexes (RECCs) that perform gRNA-directed uridine insertion and deletion during Trypanosoma brucei mitochondrial (mt) mRNA editing has a distinct endonuclease activity that requires two related RNase… read more here.
Keywords: rna editing; trypanosoma brucei; endonuclease; catalytic complexes ... See more keywords
Assembly of catalytic complexes from randomized oligonucleotides
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adu2647
Abstract: The early evolution of life relied on catalytic RNAs (ribozymes) for central functions. To test whether early catalysts could have assembled from multiple short nucleic acid fragments in random sequence environments, we performed an in… read more here.
Keywords: randomized oligonucleotides; catalytic complexes; complexes randomized; dna ... See more keywords