A Structurally Conserved Human and Tetrahymena Telomerase Catalytic Core
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2020.11.1037
Abstract: Telomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to incomplete replication. Telomerase contains a catalytic core of telomerase reverse transcriptase (TERT) and telomerase RNA (TER). However, what defines TERT and… read more here.
Keywords: telomerase catalytic; catalytic core; trap; tetrahymena telomerase ... See more keywords
Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant
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DOI: 10.1016/j.isci.2020.101555
Abstract: Summary An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu2+” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol, hydroquinone, phloroglucinol, o-phenylenediamine, 3,3′,5,5'-tetramethylbenzidine, and hydroxylamine acted… read more here.
Keywords: dna cleaving; oxidative dna; cleaving dnazyme; catalytic core ... See more keywords
Structural alterations in the catalytic core of hSIRT2 enzyme predict therapeutic benefits of Garcinia mangostana derivatives in Alzheimer's disease: molecular dynamics simulation study
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DOI: 10.1039/d0ra10459k
Abstract: Recent studies have shown that inhibition of the hSIRT2 enzyme provides favorable effects in neurodegenerative diseases such as Alzheimer's disease. Prenylated xanthone phytochemicals including α-mangostin, β-mangostin and γ-mangostin obtained from Garcinia mangostana, a well-established tropical… read more here.
Keywords: alzheimer disease; catalytic core; hsirt2 enzyme; mangostin ... See more keywords
Tetra-anionic porphyrin mimics protein-protein interactions between regulatory particles and the catalytic core, allosterically activating human 20S proteasome
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DOI: 10.1080/14756366.2025.2482892
Abstract: Abstract Decreased proteasome activity is a hallmark of brain and retinal neurodegenerative diseases (Alzheimer’s, Parkinson’s diseases, glaucoma) boosting the search for molecules acting as proteasome activators. Based on the hypothesis of an electrostatic key code… read more here.
Keywords: tetra anionic; proteasome; human 20s; catalytic core ... See more keywords
The Programmable Catalytic Core of 8-17 DNAzymes
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DOI: 10.3390/molecules29112420
Abstract: 8-17 DNAzymes (8-17, 17E, Mg5, and 17EV1) are in vitro-selected catalytic DNA molecules that are capable of cleaving complementary RNAs. The conserved residues in their similar catalytic cores, together with the metal ions, were suggested… read more here.
Keywords: programmable catalytic; pb2; catalytic core; core dnazymes ... See more keywords