Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.
Sign Up to like & getrecommendations! Published in 2022 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2022.03.007
Abstract: Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antivirals address only a fraction of the potential viral human pathogens. Here, we provide a methodology for managing human herpesvirus… read more here.
Keywords: protease; catalytic cysteine; hcmv; non catalytic ... See more keywords
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12240
Abstract: Caspases are a family of cysteine-dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human diseases. Classical chemical tools to study caspase functions lack selectivity for specific caspase family members… read more here.
Keywords: non catalytic; cysteine residue; catalytic cysteine; caspase ... See more keywords