Leukocyte recruitment induced by snake venom metalloproteinases: Role of the catalytic domain.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.144
Abstract: Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory reactions after snakebites. This study aimed to investigate the effect of SVMP domains on the alterations in leukocyte-endothelium interactions in the microcirculation of mouse… read more here.
Keywords: catalytic domain; jar; venom metalloproteinases; leukocyte recruitment ... See more keywords
Structural and biochemical characterization of the Clostridium perfringens-specific Zn2+-dependent amidase endolysin, Psa, catalytic domain.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.08.085
Abstract: Phage-derived endolysins, enzymes that degrade peptidoglycans, have the potential to serve as alternative antimicrobial agents. Psa, which was identified as an endolysin encoded in the genome of Clostridium perfringens st13, was shown to specifically lyse… read more here.
Keywords: psa catalytic; catalytic domain; clostridium perfringens; amidase ... See more keywords
Bioprocess optimization for the overproduction of catalytic domain of ubiquitin-like protease 1 (Ulp1) from S. cerevisiae in E. coli fed-batch culture.
Sign Up to like & getrecommendations! Published in 2019 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2018.10.008
Abstract: The exploitation of SUMO (small ubiquitin-related modifier) fusion technology at a large scale for the production of therapeutic proteins with an authentic N-terminus is majorly limited due to the higher cost of ScUlp1 protease. Therefore,… read more here.
Keywords: catalytic domain; bioprocess optimization; protease; sculp1 protease ... See more keywords
Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.11.007
Abstract: The single-stranded DNA (ssDNA) cytidine deaminase APOBEC3F (A3F) deaminates cytosine (C) to uracil (U) and is a known restriction factor of HIV-1. Its C-terminal catalytic domain (CD2) alone is capable of binding single-stranded nucleic acids… read more here.
Keywords: single stranded; catalytic domain; apobec3f; dna ... See more keywords
NMR study of mutations of glycine-52 of the catalytic domain of diphtheria toxin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2017.11.056
Abstract: Cross-reacting-material 197 (CRM197) is a naturally occurring non-toxic mutant of diphtheria toxin (DT) that is one of the few carrier protein used in the manufacture of polysaccharide vaccines targeting bacterial pathogens such as Neisseria meningitidis,… read more here.
Keywords: domain diphtheria; catalytic domain; domain; diphtheria toxin ... See more keywords
Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00686
Abstract: Adenosine deaminases acting on RNA (ADARs) are RNA editing enzymes that catalyze the hydrolytic deamination of adenosine (A) to inosine (I) in dsRNA. In humans, two catalytically active ADARs, ADAR1 and ADAR2, perform this A-to-I… read more here.
Keywords: modified rna; selective inhibition; rna; rna duplexes ... See more keywords
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04872-8
Abstract: The human APOBEC3G protein is a cytidine deaminase that generates cytidine to deoxy-uridine mutations in single-stranded DNA (ssDNA), and capable of restricting replication of HIV-1 by generating mutations in viral genome. The mechanism by which… read more here.
Keywords: crystal structure; catalytic domain; apobec3g; ssdna ... See more keywords
Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation approach
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2118746
Abstract: Abstract Matrix metalloproteinase-2 (MMP2), an extracellular matrix remodulating protein’s increased activity causes cancer-metastasis. Potential MMP2 inhibitors showed sever side-effects in clinical trials. Present study is focused on identification natural MMP2 inhibitor by applying molecular docking,… read more here.
Keywords: molecular docking; mmp2; catalytic domain; docking gbsa ... See more keywords
Elevated expression of the membrane-anchored serine protease TMPRSS11E in NSCLC progression.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac069
Abstract: TMPRSS11E was found to be upregulated in human non-small cell lung cancer samples (NSCLC) and cell lines, and high expression was associated with poor survival of NSCLC patients. The results of in vitro and in… read more here.
Keywords: elevated expression; expression membrane; expression; catalytic domain ... See more keywords
Structural and biochemical characterizations of the novel autolysin Acd24020 from Clostridioides difficile and its full‐function catalytic domain as a lytic enzyme
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Microbiology"
DOI: 10.1111/mmi.14636
Abstract: Autolysin is a lytic enzyme that hydrolyzes peptidoglycans of the bacterial cell wall, with a catalytic domain and cell wall‐binding (CWB) domains, to be involved in different physiological functions that require bacterial cell wall remodeling.… read more here.
Keywords: catalytic domain; autolysin acd24020; acd24020; lytic enzyme ... See more keywords
Axonal Polyneuropathy in 2 Brothers With a Homozygous Missense Variant in the First Catalytic Domain of PCYT2
Sign Up to like & getrecommendations! Published in 2022 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000000658
Abstract: Background and Objectives To expand the phenotype and genotype associated with PCYT2-related disorder. Methods Exome sequencing data from a patient with molecularly undiagnosed complex spastic paraplegia and axonal motor and sensory polyneuropathy were analyzed. Clinical… read more here.
Keywords: homozygous missense; related disorder; variant; pcyt2 related ... See more keywords