Elucidating the Protonation State of the γ-Secretase Catalytic Dyad.
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DOI: 10.1021/acschemneuro.2c00563
Abstract: γ-Secretase (GS) is an intramembrane aspartyl protease that participates in the sequential cleavage of C99 to generate different isoforms of the amyloid-β (Aβ) peptides that are associated with the development of Alzheimer's disease. Due to… read more here.
Keywords: catalytic dyad; state; elucidating protonation; secretase ... See more keywords
Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand Interactions
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DOI: 10.3390/ijms23042392
Abstract: As the etiological agent for the coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenges the ongoing efforts of vaccine development and drug design. Due to the accumulating cases of breakthrough infections, there… read more here.
Keywords: catalytic dyad; discovery sars; cov 3clpro; dyad histidine ... See more keywords