RuCu Nanosheets with Ultra-high Nanozyme Activity for Chemodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300490
Abstract: Nanoenzymes have been widely explored for chemodynamic therapy (CDT) in cancer treatment. However, poor catalytic efficiency of nanoenzymes, especially in the tumor microenvironment with insufficient H2 O2 and mild acidity, limits the effect of CDT.… read more here.
Keywords: rucu nanosheets; catalytic efficiency; therapy; rucu nss ... See more keywords
Construction of Hierarchically Porous Nanoparticles@Metal-Organic Frameworks Composites by Inherent Defects for the Enhancement of Catalytic Efficiency.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201803263
Abstract: Nanoparticles@metal-organic frameworks (MOFs) composites have attracted considerable attention in recent years due to the prominent selective catalytic activity. However, it is highly desirable to develop a simple and universal way to settle the trade-off between… read more here.
Keywords: nanoparticles metal; metal organic; inherent defects; hierarchically porous ... See more keywords
Rational identification of a high catalytic efficiency leucine dehydrogenase and process development for efficient synthesis of l‐phenylglycine
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology Journal"
DOI: 10.1002/biot.202200465
Abstract: Enzymatic asymmetric synthesis of chiral amino acids has great industrial potential. However, the low catalytic efficiency of high‐concentration substrates limits their industrial application. Herein, using a combination of substrate catalytic efficiency prediction based on “open… read more here.
Keywords: catalytic efficiency; process development; substrate; leucine dehydrogenase ... See more keywords
Ile258Met mutation of Brucella melitensis 7α-hydroxysteroid dehydrogenase significantly enhances catalytic efficiency, cofactor affinity, and thermostability.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11299-7
Abstract: NAD(H)-dependent 7α-hydroxysteroid dehydrogenase catalyzes the oxidation of chenodeoxycholic acid to 7-oxolithocholic acid. Here, we designed mutations of Ile258 adjacent to the catalytic pocket of Brucella melitensis 7α-hydroxysteroid dehydrogenase. The I258M variant gave a 4.7-fold higher… read more here.
Keywords: catalytic efficiency; hydroxysteroid dehydrogenase; thermostability; mutation ... See more keywords
Improving the catalytic efficiency and substrate affinity of a novel esterase from marine Klebsiella aerogenes by random and site-directed mutation
Sign Up to like & getrecommendations! Published in 2021 at "World Journal of Microbiology and Biotechnology"
DOI: 10.1007/s11274-021-03069-4
Abstract: A novel esterase ( Est Ka) from marine Klebsiella aerogenes was characterized with hydrolytic activity against p -nitrophenyl caprylate ( p NPC, C 8 ) under optimum conditions (50 °C and pH 8.5). After two rounds… read more here.
Keywords: catalytic efficiency; esterase; activity; substrate affinity ... See more keywords
Asn57 N-glycosylation promotes the degradation of hemicellulose by β-1,3–1,4-glucanase from Rhizopus homothallicus
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-022-19959-5
Abstract: N-glycosylation alters the properties of different enzymes in different ways. Rhizopus homothallicus was first described as an environmental isolate from desert soil in Guatemala. A new gene encoding glucanase RhGlu16B was identified in R. homothallicus.… read more here.
Keywords: glycosylation; catalytic efficiency; gh16 family; glucanase ... See more keywords
Computationally exploring the role of S-dopant and S-linker in activating the catalytic efficiency of graphene quantum dot for ORR
Sign Up to like & getrecommendations! Published in 2021 at "Catalysis Today"
DOI: 10.1016/j.cattod.2021.03.001
Abstract: Abstract To enhance the catalytic efficiency of graphene quantum dot (GQD) for ORR, the role of S-dopant and S-linker is explored here by utilizing the first-principles density functional theory-based approach. The ORR efficiency is found… read more here.
Keywords: efficiency graphene; role; graphene quantum; dopant ... See more keywords
An OPAA enzyme mutant with increased catalytic efficiency on the nerve agents sarin, soman, and GP.
Sign Up to like & getrecommendations! Published in 2018 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.11.001
Abstract: The wild-type OPAA enzyme has relatively high levels of catalytic activity against several organophosphate G-type nerve agents. A series of mutants containing replacement amino acids at the OPAA Y212, V342, and I215 sites showed several… read more here.
Keywords: catalytic efficiency; nerve agents; opaa enzyme; sarin soman ... See more keywords
Significantly improved catalytic efficiency of caffeic acid O-methyltransferase towards N-acetylserotonin by strengthening its interactions with the unnatural substrate's terminal structure.
Sign Up to like & getrecommendations! Published in 2019 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2019.02.005
Abstract: O-Methylation of N-acetylserotonin (NAS) has been identified as the bottleneck in melatonin biosynthesis pathway. In the present paper, caffeic acid O-methyltransferase from Arabidopsis thaliana (AtCOMT) was engineered by rational design to improve its catalytic efficiency… read more here.
Keywords: caffeic acid; acid methyltransferase; terminal structure; structure ... See more keywords
A pH-stable, detergent and chelator resistant type I pullulanase from Bacillus pseudofirmus 703 with high catalytic efficiency.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.11.139
Abstract: Pullulanase with high catalytic efficiency has attracted great attention from both the academic and industrial communities for its wide application in cold starch hydrolysis. A novel pullulanase gene pul703 was cloned from a mesophilic bacteria… read more here.
Keywords: pullulanase; bacillus pseudofirmus; high catalytic; pul703 ... See more keywords
SS-mPEG chemical modification of recombinant phospholipase C for enhanced thermal stability and catalytic efficiency.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.01.134
Abstract: PEGylation is one of the most promising and extensively studied strategies for improving the properties of proteins as well as enzymic physical and thermal stability. Phospholipase C, hydrolyzing the phospholipids offers tremendous applications in diverse… read more here.
Keywords: chemical modification; stability; thermal stability; catalytic efficiency ... See more keywords