Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion
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DOI: 10.1371/journal.pgen.1009016
Abstract: Several ABC exporters carry a degenerate nucleotide binding site (NBS) that is unable to hydrolyze ATP at a rate sufficient for sustaining transport activity. A hallmark of a degenerate NBS is the lack of the… read more here.
Keywords: nucleotide binding; catalytic glutamate; site; activity ... See more keywords