Catalytic Intermolecular Asymmetric [2π + 2σ] Cycloadditions of Bicyclo[1.1.0]butanes: Practical Synthesis of Enantioenriched Highly Substituted Bicyclo[2.1.1]hexanes.
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DOI: 10.1021/jacs.4c10968
Abstract: The high percentage of sp3-hybridized carbons and the presence of chiral carbon centers could contribute to increased molecular complexity, enhancing the likelihood of clinical success of drug candidates. Three-dimensional (3D) bridged motifs have recently garnered… read more here.
Keywords: bicyclo; highly substituted; bicyclo butanes; intermolecular asymmetric ... See more keywords
Catalytic Intermolecular Hydrofunctionalizations of Ynamides
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DOI: 10.1039/d4qo00301b
Abstract: Ynamides are electron-rich alkynes with carbon-carbon triple bond directly attached to the nitrogen atom bearing an electron-withdrawing group. This unique structure renders diverse reactivites of ynamides in synthetic chemistry. Among... read more here.
Keywords: catalytic intermolecular; chemistry; hydrofunctionalizations ynamides; intermolecular hydrofunctionalizations ... See more keywords