O‐GlcNAc Transferase: Structural Characteristics, Catalytic Mechanism and Small‐Molecule Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000194
Abstract: Modifications of nuclear and cytoplasmic proteins with a single sugar, N‐acetylglucosamine (GlcNAc), play roles in a wide variety of fundamental cellular processes, and aberrant O‐GlcNAc profiles are associated with pathological progression of several chronic diseases.… read more here.
Keywords: glcnac transferase; catalytic mechanism; structural characteristics; transferase structural ... See more keywords
Structural studies on M. tuberculosis argininosuccinate lyase and its liganded complex: Insights into catalytic mechanism
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DOI: 10.1002/iub.2000
Abstract: Argininosuccinate lyase catalyses the reversible breakdown of argininosuccinate into arginine and fumarate and is known to form tetramers in its quaternary association. The absence of structures involving competent enzymes bound to substrate/products came in the… read more here.
Keywords: studies tuberculosis; mechanism; catalytic mechanism; structural studies ... See more keywords
Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4338
Abstract: DcsB, an enzyme produced from the d‐cycloserine biosynthetic gene cluster, displays moderate similarity to arginase in the sequence and three‐dimensional structure. Arginase is a ubiquitous enzyme hydrolyzing l‐arginine to generate l‐ornithine and urea, whereas DcsB… read more here.
Keywords: arginase; dcsb; inhibitor; catalytic mechanism ... See more keywords
Towards Understanding the Catalytic Mechanism of Human Paraoxonase 1: Experimental and In Silico Mutagenesis Studies
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DOI: 10.1007/s12010-017-2424-5
Abstract: Human paraoxonase 1 (h-PON1) is a ~45-kDa serum enzyme that can hydrolyze a variety of substrates, including organophosphate (OP) compounds. It is a potential candidate for the development of antidote against OP poisoning in humans.… read more here.
Keywords: human paraoxonase; catalytic mechanism; hydrolyzing activity;
Structure, catalytic mechanism, posttranslational lysine carbamylation, and inhibition of dihydropyrimidinases.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2020.05.002
Abstract: Dihydropyrimidinase catalyzes the reversible hydrolytic ring opening of dihydrouracil and dihydrothymine to N-carbamoyl-β-alanine and N-carbamyl-β-aminoisobutyrate, respectively. Dihydropyrimidinase from microorganisms is normally known as hydantoinase because of its role as a biocatalyst in the synthesis of… read more here.
Keywords: dihydropyrimidinase; mechanism; catalytic mechanism; inhibition ... See more keywords
Activation of peroxymonosulfate by CuFe2O4-CoFe2O4 composite catalyst for efficient bisphenol a degradation: Synthesis, catalytic mechanism and products toxicity assessment
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.130093
Abstract: Abstract In this research, the CuFe2O4-CoFe2O4 metallic oxides catalyst (donated as CCF) was synthesized by solvothermal method and applied to degrade bisphenol A (BPA) by activating peroxymonosulfate (PMS). The different influences containing initial PMS concentration,… read more here.
Keywords: catalyst; cufe2o4 cofe2o4; bpa; degradation ... See more keywords
Activation of peroxymonosulfate by Fe78Si9B13 metallic glass: The influence of crystallization
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Alloys and Compounds"
DOI: 10.1016/j.jallcom.2017.09.019
Abstract: Abstract Exploring functional applications as heterogeneous catalysts is an active topic for metallic glasses (MGs). Although recent advances have shown that the MGs with disordered atomic packing structure are indeed having superior catalytic reactivity for… read more here.
Keywords: peroxymonosulfate; mechanism; catalytic mechanism; glassy ribbons ... See more keywords
Purification, identification, characterization and catalytic mechanism of two lipases from rice bran (Oryza sativa)
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DOI: 10.1016/j.lwt.2020.110693
Abstract: Abstract The efficient utilization of rice bran is severely impeded because of the rapid rancidity caused by rice bran lipase, so the investigation of rice bran lipase characteristic and catalytic mechanism was urgently required. The… read more here.
Keywords: catalytic mechanism; rice bran; bran; two lipases ... See more keywords
Biochemical and structural characterization of L-2-keto-3-deoxyarabinonate dehydratase: A unique catalytic mechanism in the Class I aldolase protein superfamily.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00515
Abstract: L-2-Keto-3-deoxyarabinonate (L-KDA) dehydratase (AraD) catalyzes the hydration of L-KDA to α-ketoglutaric semialdehyde in the non-phosphorylative L-arabinose pathway from bacteria, and belongs to the dihydrodipicolinate synthase (DHDPS)/N-acetylneuraminate lyase (NAL) protein superfamily. All members of this superfamily,… read more here.
Keywords: catalytic mechanism; keto deoxyarabinonate; dehydratase; keto ... See more keywords
Understanding the Catalytic Mechanism and the Substrate Specificity of an Engineered Gluten Hydrolase by QM/MM Molecular Dynamics and Free Energy Simulations
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00167
Abstract: Celiac sprue, also known as gluten-sensitive enteropathy, is a chronic disease suffered by approximately 1% of the world's population. Engineered enzymes have been emerging to treat celiac disease by hydrolyzing the pathogenic peptides of gluten.… read more here.
Keywords: catalytic mechanism; free energy; substrate specificity;
Insights into the Catalytic Mechanism of Domains CD1 and CD2 in Histone Deacetylase 6 from Quantum Calculations
Sign Up to like & getrecommendations! Published in 2021 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c04729
Abstract: The histone deacetylase 6 enzyme, HDAC6, is a metalloprotein with multiple pathophysiological roles and, as such, is the subject of intense research and drug discovery efforts. Different from the H... read more here.
Keywords: insights catalytic; histone deacetylase; mechanism domains; histone ... See more keywords