Catalytic Promiscuity of Horseradish Peroxidase: Aerobic Oxidative Regeneration of Oxidized Nicotinamide Cofactors
Sign Up to like & getrecommendations! Published in 2023 at "ChemCatChem"
DOI: 10.1002/cctc.202300330
Abstract: NAD(P)+ regeneration is of great importance for dehydrogenase (DH)‐catalyzed oxidations. In this work, we report horseradish peroxidase (HRP)‐catalyzed aerobic oxidation of the reduced nicotinamide cofactors, including natural and non‐natural ones, into the oxidized form at… read more here.
Keywords: regeneration; nicotinamide cofactors; horseradish peroxidase; promiscuity horseradish ... See more keywords
Dehydrogenase-Catalyzed Oxidation of Furanics: Exploitation of Hemoglobin Catalytic Promiscuity.
Sign Up to like & getrecommendations! Published in 2017 at "ChemSusChem"
DOI: 10.1002/cssc.201701288
Abstract: The catalytic promiscuity of hemoglobin (Hb) was explored for regenerating oxidized nicotinamide cofactors [NAD(P)+ ]. With H2 O2 as oxidant, Hb efficiently oxidized NAD(P)H into NAD(P)+ within 30 min. The new NAD(P)+ regeneration system was coupled… read more here.
Keywords: catalytic promiscuity; catalyzed oxidation; dehydrogenase catalyzed; oxidation ... See more keywords
Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.02.021
Abstract: The view of enzymes as punctilious catalysts has been shifting as examples of their promiscuous behavior increase. However, unlike a number of cases where the physiological relevance of breached substrate specificity is questionable, the very… read more here.
Keywords: promiscuity; promiscuity heme; catalytic promiscuity; synthesis ... See more keywords
Catalytic promiscuity of a copper(II)-Mannich base complex having unprecedented radical pathway in catecholase activity
Sign Up to like & getrecommendations! Published in 2020 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2020.119480
Abstract: Abstract A flexible single-side Mannich base ligand namely 4-(tert-butyl)-2-((ethyl(2-hydroxyethyl)amino)methyl)phenol (H2L) having O, N, O donor sites has been designed and synthesized using 4-(tert-butyl)phenol, formaldehyde and 2-(ethylamino)ethanol as precursors with the view to prepare polynuclear complex(s).… read more here.
Keywords: mannich base; copper; complex; tert butyl ... See more keywords
The importance of catalytic promiscuity for enzyme design and evolution
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DOI: 10.1038/s41570-019-0143-x
Abstract: The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely played a crucial role in organisms’ abilities to adapt to changing external stimuli in the past and can still be observed in extant… read more here.
Keywords: importance catalytic; evolution; enzyme design; promiscuity ... See more keywords