Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2019-000277
Abstract: Background The generation of antigen-specific cytotoxic T lymphocyte (CTL) responses is required for successful cancer vaccine therapy. In this regard, ligands of Toll-like receptors (TLRs) have been suggested to activate adaptive immune responses by modulating… read more here.
Keywords: human cysteinyl; trna synthetase; cancer; cysteinyl trna ... See more keywords
Interaction of the Lysophospholipase PNPLA7 with Lipid Droplets through the Catalytic Region
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DOI: 10.14348/molcells.2020.2283
Abstract: Mammalian patatin-like phospholipase domain containing proteins (PNPLAs) play critical roles in triglyceride hydrolysis, phospholipids metabolism, and lipid droplet (LD) homeostasis. PNPLA7 is a lysophosphatidylcholine hydrolase anchored on the endoplasmic reticulum which associates with LDs through… read more here.
Keywords: pnpla7 lds; pnpla7; catalytic region; interaction lysophospholipase ... See more keywords
Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.598998
Abstract: Despite class A ESBLs carrying substitutions outside catalytic regions, such as Cys69Tyr or Asn136Asp, have emerged as new clinical threats, the molecular mechanisms underlying their acquired antibiotics-hydrolytic activity remains unclear. We discovered that this non-catalytic-region… read more here.
Keywords: esbls; region mutations; non catalytic; class ... See more keywords