Catalytic Ynone-Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines.
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DOI: 10.1021/acs.orglett.0c03711
Abstract: A Ca(OTf)2- and self-promoted ynone-amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity… read more here.
Keywords: ynone amidine; formal cycloaddition; tricyclic azepines; amidine formal ... See more keywords