Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations.
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DOI: 10.1016/j.str.2020.01.010
Abstract: Class I phosphoinositide-3-kinases (PI3Ks) phosphorylate PIP2 at its 3' inositol position to generate PIP3, a second messenger that influences signaling cascades regulating cellular growth, survival, and proliferation. Previous studies have suggested that PI3Kα activation involves… read more here.
Keywords: pi3k; activation pi3k; allosteric activation; nsh2 domain ... See more keywords