Ketoreductase-Catalyzed Access to Axially Chiral 2,6-Disubstituted Spiro[3.3]heptane Derivatives.
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DOI: 10.1021/acs.orglett.2c01378
Abstract: The desymmetrization of a prochiral 6-oxaspiro[3.3]heptane-2-carboxylic acid derivative via biocatalytic ketoreductase-mediated reduction has provided access to both enantiomers in high ee. The axially chiral alcohol was converted to the corresponding ester alcohol, amino acid, and… read more here.
Keywords: ketoreductase catalyzed; catalyzed access; heptane; axially chiral ... See more keywords
Carbene-Catalyzed Access to Thiochromene Derivatives: Control of Reaction Pathways via Slow Release of Thiols from Disulfides.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01414
Abstract: Substrates containing disulfide bonds, which are more stable and less smelling, could be used as thiophenol precursors in organic synthesis. Herein, an N-heterocyclic carbene (NHC)-catalyzed reaction between α-bromoenals and 2,2'-dithiodibenzaldehydes was developed. Through the sustained… read more here.
Keywords: catalyzed access; reaction; carbene catalyzed; thiochromene derivatives ... See more keywords
Gold-Catalyzed Access to 1H-Isochromenes: Reaction Development and Mechanistic Insight
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DOI: 10.1021/acscatal.6b02636
Abstract: The gold-catalyzed domino cyclization/nucleophilic reaction of ortho-carbonylalkynylaryls has been studied. Thus, 2-(pyridin-2-ylethynyl)benzaldehyde has been chosen to isolate key intermediates that may take part in the reaction mechanism. Employing Hantzsch ester (HEH) as nucleophile, it has… read more here.
Keywords: isochromenes reaction; reaction; gold; catalyzed access ... See more keywords
Ionic-Liquid-Catalyzed Access to CTr: An Antitumor Agent
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DOI: 10.1021/acssuschemeng.1c00191
Abstract: CTr (5,6,11,12,17,18-hexahydrocyclononal[1,2-b:4,5-b′:7,8-b″]triindole) is a unique 9-membered indole-fused cycloalkane alkaloid with improved druglike privilege and therapeutic potential, but its ... read more here.
Keywords: ctr antitumor; liquid catalyzed; access ctr; antitumor agent ... See more keywords
Manganese(i)-catalyzed access to 1,2-bisphosphine ligands
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc06694c
Abstract: Chiral bisphosphine ligands are of key importance in transition-metal-catalyzed asymmetric synthesis of optically active products. However, the transition metals typically used are scarce and expensive noble metals, while the synthetic routes to access chiral phosphine… read more here.
Keywords: manganese catalyzed; catalyzed access; access bisphosphine; bisphosphine ... See more keywords