Origins of chemoselectivity of Rh(III)-Catalyzed C–H activation of N-(pivaloyloxy)benzamide: Insights from density functional theory calculations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2018.11.011
Abstract: Abstract An unprecedented Rh(III)-catalyzed C–H activation of N-(pivaloyloxy)benzamide was recently reported by Feng et al. In this transformation, the substituent on the alkyne controls the chemoselectivity (annulation or hydroarylation). Given the importance of this novel strategy,… read more here.
Keywords: iii catalyzed; chemoselectivity; catalyzed activation; activation pivaloyloxy ... See more keywords
Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles using enol as directing group: A straightforward approach to difunctionalized cyclopentenes
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.02.063
Abstract: Abstract A Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles with o-vinylphenols as an efficient approach to alkenyl-substituted aminocyclopentenes is reported. This protocol represents another classic example for direct C–H activation of terminal alkenes using enol as directing… read more here.
Keywords: desymmetrization diazabicycles; using enol; iii catalyzed; catalyzed activation ... See more keywords
Cobalt-catalyzed C H activation/C O formation: Synthesis of benzofuranones
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151396
Abstract: Abstract Herein, C H activation/C O formation reaction using novel cobalt catalytic system is reported. This reaction was given benzofuranones in moderate to excellent yields at room-temperature under air reaction conditions. The introduced strategy is… read more here.
Keywords: formation synthesis; cobalt catalyzed; catalyzed activation; activation ... See more keywords
Intermolecular Difunctionalization of C,C-Palladacycles Obtained by Pd(0)-Catalyzed C-H Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00627
Abstract: ConspectusC,C-Palladacycles are an important class of organometallic compounds in which palladium is σ-bonded to two carbon atoms. They have three notable features that make them attractive in organic synthesis and organometallic chemistry: (1) C,C-Palladacycles are… read more here.
Keywords: reactions palladacycles; intermolecular difunctionalization; chemistry; catalyzed activation ... See more keywords
Rh(III)-Catalyzed C-H Activation/[3 + 2] Annulation of N-Phenoxyacetamides via Carbooxygenation of 1,3-Dienes.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00945
Abstract: A unique Rh(III)-catalyzed C-H activation/[3 + 2] annulation of N-phenoxyacetamides has been developed for the construction of dihydrobenzofurans via carbooxygenation of 1,3-dienes. This transformation features a redox-neutral process with specific chemoselectivity, good substrate/functional group compatibility,… read more here.
Keywords: carbooxygenation dienes; iii catalyzed; catalyzed activation; activation annulation ... See more keywords
Construction of Peptide-Isoquinolone Conjugates via Rh(III)-Catalyzed C-H Activation/Annulation.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00766
Abstract: Herein, we disclose a Rh(III)-catalyzed C-H activation/annulation reaction for the derivatization of Lys-based peptides, in situ affording diverse peptide-isoquinolone conjugates. This approach features racemization-free conditions, high atom- and step-economy, excellent chemo- and site-selectivity, and broad… read more here.
Keywords: isoquinolone; peptide isoquinolone; catalyzed activation; isoquinolone conjugates ... See more keywords
Rhodium(III)-Catalyzed C-H Activation/Heterocyclization as a Macrocyclization Strategy. Synthesis of Macrocyclic Pyridones.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01051
Abstract: Structurally diverse macrocyclic pyridones can be efficiently synthesized by a rhodium(III)-catalyzed C-H activation/heterocyclization of ω-alkynyl α-substituted acrylic hydroxamates. The use of a O-pivaloyl hydroxamate as directing group was crucial to achieve efficient catalyst turnover in… read more here.
Keywords: activation heterocyclization; iii catalyzed; catalyzed activation; macrocyclic pyridones ... See more keywords
Regio- and Diastereoselective Access to Fused Isoxazolidines via Ru(II)-Catalyzed C-H Activation of Nitrones and Coupling with Perfluoroalkylolefins.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03775
Abstract: The synthsis of fluorinated isoxazolidines in bicyclic settings has been realized via Ru(II)-catalyzed C-H activation of aryl nitrones with perfluoroalkyl-substituted olefins as the coupling partner. The reaction proceeded via initial chelation-assisted C(aryl)-H allylation followed by… read more here.
Keywords: diastereoselective access; via catalyzed; regio diastereoselective; catalyzed activation ... See more keywords
Bisannulation of Benzamides and Cyclohexadienone-Tethered Allenes Triggered by Cp*Rh(III)-Catalyzed C-H Activation and Relay Ene Reaction.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00083
Abstract: The diastereoselective bisannulation of N-(pivaloyloxy)benzamides and cyclohexadienone-tethered allenes was accomplished through Cp*Rh(III)-catalyzed C-H activation and relay ene reaction, providing a 3-isoquinolonyl cis-hydrobenzofuran framework with high yields and diastereoselectivities. This reaction tolerates a wide range of… read more here.
Keywords: iii catalyzed; tethered allenes; catalyzed activation; benzamides cyclohexadienone ... See more keywords
Tandem C-C/C-N Formation via Palladium-Catalyzed C-H Activation/Styrenation and Sequential Annulation of O-Methylketoxime with Styrenes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00702
Abstract: A novel route for tandem C-C/C-N formation via palladium-catalyzed C-H activation/styrenation and annulation of O-methylketoxime with styrenes to synthesize benzothienopyridines and benzofuropyridines has been developed. Furthermore, the intermolecular alkenylation of the ketoxime with acrylates produces… read more here.
Keywords: formation via; activation styrenation; via palladium; tandem formation ... See more keywords
Co(III)-Catalyzed C–H Activation: A Site-Selective Conjugate Addition of Maleimide to Indole at the C-2 Position
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b00870
Abstract: The cobalt(III)-catalyzed site-selective C-2 functionalization of indole has been developed using the pyrimidinyl group as a directing group. This reaction furnishes 3-arylated succinimide derivatives in excellent yields in a shorter duration using an inexpensive Co… read more here.
Keywords: activation site; site selective; position; iii catalyzed ... See more keywords