Palladium-Catalyzed Alkenyl C-H Activation/Diamination toward Tetrahydrocarbazole and Analogs Using Hydroxylamines as Single-Nitrogen Sources.
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DOI: 10.1021/acs.orglett.2c03809
Abstract: A palladium-catalyzed alkenyl C-H activation/diamination reaction of cycloalkenyl bromoarenes with hydroxylamines is described. A wide range of tetrahydrocarbazoles and analogs has been prepared using fine-tuning bifunctional secondary hydroxylamines as the single-nitrogen sources. Mechanistic investigations suggest… read more here.
Keywords: alkenyl activation; activation diamination; palladium catalyzed; catalyzed alkenyl ... See more keywords
Rhodium-Catalyzed Z-Alkenyl 1,3-Migration.
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DOI: 10.1021/acs.orglett.5c02468
Abstract: Strategies for the selective cleavage of inert C-C bonds in tertiary alcohols have been developed. However, a gap remains in Z-alkenyl 1,3-migration through selective C(sp3)-C(Z-alkenyl) bond cleavage. Herein, we report rhodium-catalyzed Z-alkenyl 1,3-migration, which efficiently… read more here.
Keywords: rhodium catalyzed; migration; catalyzed alkenyl; alkenyl migration ... See more keywords
Regiodivergent Synthesis of Eight-Membered Benzosilacycles via Palladium-Catalyzed Alkenyl C(sp2)-H Activation.
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DOI: 10.1021/acs.orglett.5c02531
Abstract: Herein we report a general and efficient method for the regiodivergent synthesis of medium-sized eight-membered aryl- and alkenylsilacycles via a palladium-catalyzed alkenyl C(sp2)-H activation/ring expansion cascade. This protocol features a broad substrate scope regarding o-bromostyrenes… read more here.
Keywords: eight membered; palladium catalyzed; regiodivergent synthesis; alkenyl sp2 ... See more keywords