Iridium-Catalyzed Amidation of In Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters.
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DOI: 10.1021/acs.orglett.1c04376
Abstract: Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst.… read more here.
Keywords: catalyzed amidation; silyl ketene; ketene acetals; access ... See more keywords
Amide-Directed Cobalt(III)-Catalyzed C-H Amidation of Ferrocenes.
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DOI: 10.1021/acs.orglett.8b03938
Abstract: The amide-directed cobalt(III)-catalyzed C-H amidation of ferrocene carboxamides using 1,4,2-dioxazol-5-ones as robust and efficient amidating reagents has been developed. This reaction proceeds efficiently under mild reaction conditions with good functional group tolerance, providing expedient access… read more here.
Keywords: amide directed; catalyzed amidation; directed cobalt; iii catalyzed ... See more keywords
Rh(III)-Catalyzed C-H Amidation of Arenes with N-Methoxyamide as an Amidating Reagent.
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DOI: 10.1021/acs.orglett.9b02625
Abstract: The Rh(III)-catalyzed amidation of C(sp2)-H bonds has been reported by employing the N-methoxyamide as a novel amino source. An excellent level of functional group tolerance can be achieved when N-methoxyamide derivatives are used as the… read more here.
Keywords: amidation arenes; catalyzed amidation; iii catalyzed; methoxyamide amidating ... See more keywords
Mechanistic Insights into La-Catalyzed Amidation of Aldehyde with Amine.
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DOI: 10.1021/acs.orglett.9b04445
Abstract: A new mechanism of La-catalyzed amidation of N-methylbenzylamine with p-chlorobenzaldehyde has been computationally proposed, where L2La[NR1R2] (I) rather than previously proposed L2La[OCHRNR1R2] (II) is the catalytically active species. Interestingly, the side-product alcohol acting as a… read more here.
Keywords: amidation aldehyde; catalyzed amidation; insights catalyzed; aldehyde amine ... See more keywords
Nickel-Catalyzed Amidation of Aryl Alkynyl Acids with Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides
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DOI: 10.1021/acsomega.2c07353
Abstract: Nickel-catalyzed amidation of aryl alkynyl acids using tetraalkylthiuram disulfides as the amine source is described, affording a series of aryl alkynyl amides in good to excellent yields under mild conditions. This general methodology provides an… read more here.
Keywords: alkynyl amides; aryl; nickel catalyzed; synthesis ... See more keywords
Copper-catalyzed α-C–H amidation of simple ethers through C(sp3)–H/N–H cross dehydrogenative coupling
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DOI: 10.1039/c7qo01003f
Abstract: An efficient copper-catalyzed α-C–H amidation of simple ethers with N-(8-quinolyl)amides through C(sp3)–H/N–H cross dehydrogenative coupling was developed. Chelation assistance was employed for the formation of an active copper amide species which can couple with the… read more here.
Keywords: amidation simple; simple ethers; simple; catalyzed amidation ... See more keywords
Dithiane-directed Rh(iii)-catalyzed amidation of unactivated C(sp3)–H bonds† †Electronic supplementary information (ESI) available: Experimental protocol and spectra data. See DOI: 10.1039/c8sc05225e
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc05225e
Abstract: A Rh(iii) catalysed dithiane directed C(sp3)–H amidation for the synthesis of usefully protected β-aminoaldehyde derivatives is described. read more here.
Keywords: catalyzed amidation; iii catalyzed; dithiane; dithiane directed ... See more keywords