Highly Diastereoselective Functionalization of Piperidines by Photoredox Catalyzed α-Amino C-H Arylation and Epimerization.
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DOI: 10.1021/jacs.9b13165
Abstract: We report a photoredox catalyzed α-amino C-H arylation reaction of highly substituted piperidine derivatives with electron deficient cyano(hetero)arenes. The scope and limitations of the reaction were explored, with piperidines bearing multiple substitution patterns providing the… read more here.
Keywords: amino arylation; catalyzed amino; epimerization; arylation ... See more keywords