On the Barton Copper-Catalyzed C3-Arylation of Indoles using Triarylbismuth bis(trifluoroacetate) Reagents.
Sign Up to like & getrecommendations! Published in 2023 at "ChemPlusChem"
DOI: 10.1002/cplu.202300218
Abstract: Invited for this month's cover are the collaborating groups of Prof. Alexandre Gagnon at the Université du Québec à Montréal in Canada, and Dr. Claire McMullin at the University of Bath in the UK. The… read more here.
Keywords: copper; indoles using; arylation indoles; catalyzed arylation ... See more keywords
Synthesis of reversible PAD4 inhibitors via copper-catalyzed C−H arylation of benzimidazole
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9409-3
Abstract: PAD4 is a promising epigenetic drug target for various cancers and immune diseases. In this work, we applied a Cu-catalyzed C–H arylation reaction of N-heteroarene to the synthesis of complex non-covalent PAD4 inhibitors bearing a… read more here.
Keywords: pad4; synthesis; pad4 inhibitors; catalyzed arylation ... See more keywords
Promotion Mechanism of H2O for Stereoselectivity in Pd(II)-catalyzed C―H Arylation of Diarylphosphinamides with Arylboronic Acids
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-9013-9
Abstract: On the basis of a series of control experiments and nuclear magnetic resonance analyses, it is discovered that Boc-protected amino acid ligand coordinated to Pd center is partly replaced by N,N-dimethylformamide, and H2O can inhibit… read more here.
Keywords: mechanism; arylation diarylphosphinamides; stereoselectivity catalyzed; arylboronic acids ... See more keywords
Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00122
Abstract: N,N'-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between aryl iodides and aryl bromides,… read more here.
Keywords: hetero aryl; amides hetero; aryl iodides; catalyzed arylation ... See more keywords
Ru-Catalyzed C-H Arylation of Acrylic Acids with Aryl Bromides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01043
Abstract: In the presence of a [Ru(p-cymene)Cl2]2/triethylphosphine/lithium carbonate catalyst system, aryl bromides undergo (Z)-selective couplings with unprotected 2-arylacrylic acids to form (Z)-diarylacrylic acids. This vinylic C-H functionalization proceeds in high yields of up to 94% and… read more here.
Keywords: acrylic acids; acids aryl; arylation acrylic; catalyzed arylation ... See more keywords
Palladium Metallaphotoredox-Catalyzed 2-Arylation of Indole Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01674
Abstract: Given that biaryl motifs are found in many useful molecules, including pesticides, pharmaceuticals, functional materials, and polymers, the development of methods for their construction is important. Herein, we report a two-step method for C(sp2)-H/C(sp2)-H cross-coupling… read more here.
Keywords: metallaphotoredox catalyzed; arylation indole; indole derivatives; catalyzed arylation ... See more keywords
Cu/N,N'-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02509
Abstract: N,N'-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol… read more here.
Keywords: arylation heteroanilines; hetero aryl; dibenzyloxalamide catalyzed; arylation ... See more keywords
Enantioselective C,P-Palladacycle-Catalyzed Arylation of Imines
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DOI: 10.1021/acsomega.0c01124
Abstract: Chiral diarylmethylamines are of great interest because of their prevalence in biological and pharmaceutical sciences. Herein, we report a C,P-palladacycle-catalyzed enantioselective synthesis of chiral diarylmethylamines via asymmetric arylation of N-protected imines with arylboronic acids. The… read more here.
Keywords: arylation imines; enantioselective palladacycle; arylation; palladacycle catalyzed ... See more keywords
Palladium-Catalyzed α-Arylation of Cyclic β-Dicarbonyl Compounds for the Synthesis of CaV1.3 Inhibitors
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DOI: 10.1021/acsomega.2c00889
Abstract: Cyclic α-aryl β-dicarbonyl derivatives are important scaffolds in medicinal chemistry. Palladium-catalyzed coupling reactions of haloarenes were conducted with diverse five- to seven-membered cyclic β-dicarbonyl derivatives including barbiturate, pyrazolidine-3,5-dione, and 1,4-diazepane-5,7-dione. The coupling reactions of various… read more here.
Keywords: cyclic dicarbonyl; cav1; palladium catalyzed; dione ... See more keywords
Pd-catalyzed C–H arylation of benzothioamides with boronic acids using thioamides as directing groups
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DOI: 10.1039/c7qo00532f
Abstract: The Pd(II)-catalyzed C–H arylation of benzothioamides with boronic acids using thioamides as directing groups, prevalent organic motifs found in vital biological and pharmaceutical molecules, has been achieved for the first time. The reactions proceed with… read more here.
Keywords: boronic acids; arylation benzothioamides; using thioamides; acids using ... See more keywords
Deciphering the mechanism of copper-catalyzed N-arylation between aryl halides and nitriles: a DFT study
Sign Up to like & getrecommendations! Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj03860d
Abstract: The mechanism of the CuI/DMEDA-catalyzed tandem hydrolysis/N-arylation of benzonitrile with aryl iodide was studied using the DFT method. read more here.
Keywords: mechanism copper; mechanism; arylation; deciphering mechanism ... See more keywords