Rhodium(III)‐Catalyzed Arylation of Dimethyl Itaconate: Facile Access to Substituted Benzylidenesuccinates
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400589
Abstract: The rhodium(III)‐catalyzed arylation of dimethyl itaconate with arylboronic acids proceeds smoothly under mild conditions to produce benzylidenesuccinates. The present reaction provides a simple synthesis route to benzylidenesuccinates, which are of interest due to their biological… read more here.
Keywords: catalyzed arylation; dimethyl itaconate; arylation dimethyl; rhodium iii ... See more keywords
On the Barton Copper-Catalyzed C3-Arylation of Indoles using Triarylbismuth bis(trifluoroacetate) Reagents.
Sign Up to like & getrecommendations! Published in 2023 at "ChemPlusChem"
DOI: 10.1002/cplu.202300218
Abstract: Invited for this month's cover are the collaborating groups of Prof. Alexandre Gagnon at the Université du Québec à Montréal in Canada, and Dr. Claire McMullin at the University of Bath in the UK. The… read more here.
Keywords: copper; indoles using; arylation indoles; catalyzed arylation ... See more keywords
Direct Palladium‐Catalyzed C5‐Arylation of 1,3,4‐Oxadiazoles with Aryl Chlorides Promoted by Bis(diisopropylphosphino)ferrocene
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400212
Abstract: The direct palladium‐catalyzed C–H arylation of 1,3,4‐oxadiazoles with challenging aryl chloride substrates is promoted by the use of a specifically designed electron‐rich ferrocenyl diphosphane. This protocol employs 0.5 to 1.0 mol% catalyst loading without any… read more here.
Keywords: palladium catalyzed; catalyzed arylation; arylation oxadiazoles; direct palladium ... See more keywords
Synthesis of reversible PAD4 inhibitors via copper-catalyzed C−H arylation of benzimidazole
Sign Up to like & getrecommendations! Published in 2019 at "Science China Chemistry"
DOI: 10.1007/s11426-018-9409-3
Abstract: PAD4 is a promising epigenetic drug target for various cancers and immune diseases. In this work, we applied a Cu-catalyzed C–H arylation reaction of N-heteroarene to the synthesis of complex non-covalent PAD4 inhibitors bearing a… read more here.
Keywords: pad4; synthesis; pad4 inhibitors; catalyzed arylation ... See more keywords
Promotion Mechanism of H2O for Stereoselectivity in Pd(II)-catalyzed C―H Arylation of Diarylphosphinamides with Arylboronic Acids
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-9013-9
Abstract: On the basis of a series of control experiments and nuclear magnetic resonance analyses, it is discovered that Boc-protected amino acid ligand coordinated to Pd center is partly replaced by N,N-dimethylformamide, and H2O can inhibit… read more here.
Keywords: mechanism; arylation diarylphosphinamides; stereoselectivity catalyzed; arylboronic acids ... See more keywords
Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00122
Abstract: N,N'-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between aryl iodides and aryl bromides,… read more here.
Keywords: hetero aryl; amides hetero; aryl iodides; catalyzed arylation ... See more keywords
Ru-Catalyzed C-H Arylation of Acrylic Acids with Aryl Bromides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01043
Abstract: In the presence of a [Ru(p-cymene)Cl2]2/triethylphosphine/lithium carbonate catalyst system, aryl bromides undergo (Z)-selective couplings with unprotected 2-arylacrylic acids to form (Z)-diarylacrylic acids. This vinylic C-H functionalization proceeds in high yields of up to 94% and… read more here.
Keywords: acrylic acids; acids aryl; arylation acrylic; catalyzed arylation ... See more keywords
Palladium Metallaphotoredox-Catalyzed 2-Arylation of Indole Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01674
Abstract: Given that biaryl motifs are found in many useful molecules, including pesticides, pharmaceuticals, functional materials, and polymers, the development of methods for their construction is important. Herein, we report a two-step method for C(sp2)-H/C(sp2)-H cross-coupling… read more here.
Keywords: metallaphotoredox catalyzed; arylation indole; indole derivatives; catalyzed arylation ... See more keywords
Palladium-Catalyzed N-Arylation of NH-Sulfoximines with (Hetero)aryl Chlorides in an Aqueous Micellar Environment.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c00684
Abstract: An efficient Pd-catalyzed N-arylation of sulfoximines with (hetero)aryl chlorides was developed under mild aqueous conditions. This reaction proceeded smoothly with a low loading of the Pd catalyst (down to 0.5 mol %) and was completed… read more here.
Keywords: aryl chlorides; catalyzed arylation; hetero aryl; sulfoximines hetero ... See more keywords
Cu/N,N'-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02509
Abstract: N,N'-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol… read more here.
Keywords: arylation heteroanilines; hetero aryl; dibenzyloxalamide catalyzed; arylation ... See more keywords
Enantioselective C,P-Palladacycle-Catalyzed Arylation of Imines
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DOI: 10.1021/acsomega.0c01124
Abstract: Chiral diarylmethylamines are of great interest because of their prevalence in biological and pharmaceutical sciences. Herein, we report a C,P-palladacycle-catalyzed enantioselective synthesis of chiral diarylmethylamines via asymmetric arylation of N-protected imines with arylboronic acids. The… read more here.
Keywords: arylation imines; enantioselective palladacycle; arylation; palladacycle catalyzed ... See more keywords