Squaramide catalyzed α-chiral amine synthesis
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.08.034
Abstract: Abstract Enantiomerically pure α-chiral amines, have been commonly utilized as resolving agents and chiral auxiliaries and are currently found in 40% of active pharmaceutical ingredients. Hence, development of highly stereoselective metal-free protocols regarding atom-economy and… read more here.
Keywords: squaramide catalyzed; carbon; amine synthesis; chiral amine ... See more keywords
Enantioselective conjugate addition of hydroxylamines to α,β-unsaturated 2-acyl imidazoles catalyzed by a chiral-at-metal Rh(III) complex
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c6qo00865h
Abstract: A catalytic enantioselective hydroxyamination of α,β-unsaturated 2-acyl imidazoles with N-protected hydroxyl amines catalyzed by a chiral-at-metal Rh(III) complex (0.5–2 mol%) has been developed. The approach affords valuable N-Boc protected β-amino acid derivatives in moderate to… read more here.
Keywords: unsaturated acyl; catalyzed chiral; acyl imidazoles; chiral metal ... See more keywords
Asymmetric Chlorination of 4-Substituted Pyrazolones Catalyzed by Chiral Copper Complexes
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DOI: 10.1055/s-0039-1690879
Abstract: A fast and highly enantioselective chlorination of 4-pyrazolones catalyzed by bis(oxazoline)–Cu(ClO4)2·6H2O complexes has been developed. Under the optimized conditions, a series of pyrazolones bearing stereogenic chlorine-attached carbon centers were obtained in moderate to high yields… read more here.
Keywords: chlorination substituted; asymmetric chlorination; chlorination; catalyzed chiral ... See more keywords
Enantioselective Henry Reaction Catalyzed by Chiral Piperazine Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2021.7150
Abstract: A series of novel tridentate Schiff bases is synthesized from piperazine-amine and substituted salicylaldehydes, and characterized by spectroscopic methods. These chiral ligands were used to catalyze the addition of nitromethane to various aldehydes in the… read more here.
Keywords: henry reaction; piperazine derivatives; catalyzed chiral; chiral piperazine ... See more keywords