CuI/l-proline catalyzed click reaction in glycerol for the synthesis of 1,2,3-triazoles
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DOI: 10.1016/j.tetlet.2018.11.078
Abstract: Abstract Despite the apparent simplicity of the copper(I) iodide catalyzed CuAAC reaction, the conversion of the catalytic species, i.e. Cu(I) to thermodynamically more stable Cu(II), via aerial oxidation or disproportionation is a major issue. To… read more here.
Keywords: proline catalyzed; glycerol; reaction; catalyzed click ... See more keywords
Asymmetric rhodium-catalyzed click cycloaddition to access C–N axially chiral N-triazolyl indoles
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00610g
Abstract: The copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction is regarded as a prime example of “click chemistry”, but the asymmetric click cycloaddition of internal alkynes still remains challenging. A new asymmetric Rh-catalyzed click cycloaddition of N-alkynylindoles with… read more here.
Keywords: catalyzed click; click cycloaddition; axially chiral; chiral triazolyl ... See more keywords