Tandem Copper-Catalyzed Conjugate Addition-Diastereoselective Protonation of ( E)-α-Trialkylsilyl-β-Alkyl(Aryl)-α,β-Unsaturated Esters.
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DOI: 10.1021/acs.orglett.8b02527
Abstract: A tandem Cu(I)-catalyzed conjugate addition of Kharasch reagents/diastereoselective protonation of ( E)-α-trialkylsilyl-β-alkyl(aryl)-α,β-unsaturated esters afforded the saturated products with d.r. values of >20:1 favoring the anti-diastereomer in modest to excellent isolated yields. read more here.
Keywords: diastereoselective protonation; conjugate addition; catalyzed conjugate; trialkylsilyl alkyl ... See more keywords
Cu-Catalyzed Conjugate Addition of Grignard Reagents to Thiochromones: An Enantioselective Pathway for Accessing 2-Alkylthiochromanones
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DOI: 10.1055/s-0037-1610225
Abstract: The enantioselective incorporation of alkyl groups in thiochromones was realized for the first time by a Cu/(R,S)-PPF-P t Bu2-catalyzed conjugate addition of Grignard reagents to thiochromones. With this method, a series of 2-methylthiochromanones were obtained… read more here.
Keywords: reagents thiochromones; grignard reagents; conjugate addition; catalyzed conjugate ... See more keywords