One-Pot Synthesis of Indolizines via Sequential Rhodium-Catalyzed [2 + 1]-Cyclopropanation, Palladium-Catalyzed Ring Expansion, and Oxidation Reactions from Pyridotriazoles and 1,3-Dienes.
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DOI: 10.1021/acs.orglett.7b02826
Abstract: An efficient, one-pot synthetic method for producing functionalized indolizine derivatives was developed via a Rh-catalyzed [2 + 1]-cyclopropanation, Pd-catalyzed ring expansion, and subsequent oxidation using manganese dioxide from pyridotriazoles and 1,3-dienes. read more here.
Keywords: pyridotriazoles dienes; ring expansion; catalyzed ring; one pot ... See more keywords
Difluoromethylcarbene for iron-catalyzed cyclopropanation.
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DOI: 10.1039/c7cc01636k
Abstract: Difluoroethylsulfonium salt, Ph2S+CH2CF2H OTf-, was developed into a convenient difluoromethylcarbene reagent for the iron-catalyzed cyclopropanation of terminal olefins, giving various difluoromethyl-cyclopropanes with excellent diastereoselectivities and in high yields. read more here.
Keywords: difluoromethylcarbene iron; iron catalyzed; catalyzed cyclopropanation;
Chromium-catalyzed cyclopropanation of alkenes with bromoform in the presence of 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-dihydropyrazineâ€
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DOI: 10.1039/d0sc00964d
Abstract: Chromium-catalyzed cyclopropanation of alkenes with bromoform was achieved to produce the corresponding bromocyclopropanes. In this catalytic cyclopropanation, an organosilicon reductant, 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-dihydropyrazine (1a), was indispensable for reducing CrCl3(thf)3 to CrCl2(thf)3, as well as for in situ… read more here.
Keywords: cyclopropanation; chromium catalyzed; cyclopropanation alkenes; alkenes bromoform ... See more keywords
Silver-catalyzed cyclopropanation of alkenes with alkynyl N-nosylhydrazones leading to alkynyl cyclopropanes.
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DOI: 10.1039/d2cc00099g
Abstract: Here, a novel method for the stereoselective synthesis of alkynyl cyclopropanes, by the silver-catalyzed alkynylcyclopropanation of alkenes using alkynyl N-nosylhydrazones as alkynyl carbene precursors, is reported. This method provides a straightforward and powerful approach for… read more here.
Keywords: cyclopropanation alkenes; catalyzed cyclopropanation; cyclopropanes silver; silver catalyzed ... See more keywords
B(C6F5)3-catalyzed cyclopropanation of 3-alkenyl-oxindoles with diazomethanes.
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DOI: 10.1039/d2cc06744g
Abstract: Spirocyclopropane-oxindoles are key motifs in biologically active compounds and are versatile synthetic intermediates. Herein, we report a metal-free, B(C6F5)3 catalyzed cyclopropanation of 3-alkenyl-oxindoles with diazomethanes. This provides 25 variants of spirocyclopropane-oxindole derivatives. These spirocyclopropane-oxindole products… read more here.
Keywords: cyclopropanation alkenyl; catalyzed cyclopropanation; alkenyl oxindoles; c6f5 catalyzed ... See more keywords