Samarium‐Catalyzed Diastereoselective Double Addition of Phenylphosphine to Imines and Mechanistic Studies by DFT Calculations
Sign Up to like & getrecommendations! Published in 2017 at "ChemCatChem"
DOI: 10.1002/cctc.201700003
Abstract: The catalytic hydrophosphination of imines represents the most straightforward and atom‐economical strategy for the preparation of α‐aminophosphines, which are useful as biologically active molecules and ligands for catalysis. The first catalytic protocol for the rapid… read more here.
Keywords: addition; diastereoselective double; samarium catalyzed; catalyzed diastereoselective ... See more keywords
Palladium-catalyzed diastereoselective synthesis of β,β-diarylpropionic acid derivatives and its application to the total synthesis of (R)-tolterodine and the enantiomer of a key intermediate for MK-8718
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.12.082
Abstract: Abstract Palladium-catalyzed diastereoselective synthesis of optically active β,β-diarylpropionic acid derivatives employing 4-(tert-butyl)oxazolidin-2-one as the chiral auxiliary under an air atmosphere in excellent yields with high diastereoselectivity is reported. The catalytic system is applied to the… read more here.
Keywords: diastereoselective synthesis; synthesis; catalyzed diastereoselective; palladium catalyzed ... See more keywords
B(C6F5)3-Catalyzed Diastereoselective Formal (4 + 1)-Cycloaddition of Vinylcyclopropanes and Et2SiH2.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01565
Abstract: A formal (4 + 1)-cycloaddition of vinylcyclopropanes and Et2SiH2 to afford 3,4-disubstituted silolanes is reported. The reaction sequence commences with the known B(C6F5)3-catalyzed alkene hydrosilylation with dihydrosilanes. Cleavage of the remaining Si-H bond in the… read more here.
Keywords: c6f5 catalyzed; catalyzed diastereoselective; formal cycloaddition; cycloaddition vinylcyclopropanes ... See more keywords
Nickel-Catalyzed Diastereoselective Cross-Electrophile Ring Opening of 7-Oxabenzonorbornadienes with Aromatic Aldehydes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00471
Abstract: In this protocol, we developed a nickel-catalyzed diastereoselective cross-electrophile ring opening reaction of 7-oxabenzonorbornadienes with aromatic aldehydes as the electrophilic coupling partner utilizing Zn as the stoichiometric reductant. In this reaction, a challenging stereoselective bond… read more here.
Keywords: electrophile ring; nickel catalyzed; catalyzed diastereoselective; diastereoselective cross ... See more keywords
Ti-Catalyzed Diastereoselective Cyclopropanation of Carboxylic Derivatives with Terminal Olefins.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02360
Abstract: Cyclopropanols and cyclopropylamines not only serve as important structural motifs in medicinal chemistry but also show diverse reactivities in organic synthesis. Owing to the high ring strain energy, the development of a general protocol from… read more here.
Keywords: diastereoselective cyclopropanation; derivatives terminal; carboxylic derivatives; terminal olefins ... See more keywords
Lewis acid catalyzed diastereoselective [3+4]-annulation of donor-acceptor cyclopropanes with anthranils: synthesis of tetrahydro-1-benzazepine derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04239f
Abstract: A Lewis acid catalyzed [3+4]-annulation reaction between cyclopropane 1,1-diesters and anthranils has been developed. This annulation consists of a reaction sequence involving ring-opening/aromatization/nucleophilic addition. Thereinto, aromatization is the driving force for this annulation. Using this… read more here.
Keywords: annulation donor; annulation; lewis acid; catalyzed diastereoselective ... See more keywords
Ag(I)/PPh3-catalyzed diastereoselective syntheses of spiro[indole-3,4'-piperidine] derivatives via cycloisomerizations of tryptamine-ynamides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07298f
Abstract: A Ag(I)/PPh3-catalyzed chelation-controlled cycloisomerization of tryptamine-ynamide was developed to access the spiro[indole-3,4'-piperidine] scaffold in a racemic and diastereoselective manner. The diastereoselective products were achieved by a chiron approach. Density functional theory (DFT) calculations indicated that… read more here.
Keywords: diastereoselective syntheses; catalyzed diastereoselective; indole piperidine; pph3 catalyzed ... See more keywords
Rhodium-catalyzed diastereoselective synthesis of highly substituted morpholines from nitrogen-tethered allenols.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00151b
Abstract: Rhodium-catalyzed intramolecular cyclization of nitrogen-tethered allenols was investigated for the synthesis of functionalized morpholines. By using this strategy, various N-protected 2,5- and 2,6-disubstituted as well as 2,3,5- and 2,5,6-trisubstituted morpholines were obtained via an atom-economic… read more here.
Keywords: nitrogen tethered; diastereoselective synthesis; tethered allenols; catalyzed diastereoselective ... See more keywords
Lewis acid-catalyzed diastereoselective carbofunctionalization of bicyclobutanes employing naphthols
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc01373a
Abstract: Traditional radical-mediated ring-opening of bicyclo[1.1.0]butanes (BCBs) for cyclobutane synthesis suffers from poor diastereoselectivity. Although few reports on BCB ring-opening via polar mechanisms are available, the Lewis acid-catalyzed diastereoselective ring-opening of... read more here.
Keywords: diastereoselective carbofunctionalization; carbofunctionalization bicyclobutanes; catalyzed diastereoselective; lewis acid ... See more keywords