Mechanistic Insights into Ni-Catalyzed Difunctionalization of Alkenes Using Organoboronic Acids and Organic Halides: Understanding Remarkable Substrate-Dependent Regioselectivity
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DOI: 10.1021/acs.organomet.0c00043
Abstract: Transition metal catalyzed difunctionalization reactions of alkenes using simple chemical feedstocks are powerful strategies for the synthesis of valuable compounds and materials. Density functiona... read more here.
Keywords: insights catalyzed; catalyzed difunctionalization; alkenes using; mechanistic insights ... See more keywords
Borane- and Silylium-Catalyzed Difunctionalization of Carbohydrates: 3,6-Anhydrosugar Enabled 1,6-Site Selectivity.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01243
Abstract: A novel diastereoselective, Lewis acid catalyzed 1,6-difunctionalization of galactose and mannose derivatives has been developed in one pot, via sequential nucleophile additions. Our studies point to the formation of a 3,6-anhydrosugar intermediate as key to… read more here.
Keywords: borane silylium; site selectivity; catalyzed difunctionalization;
Electrochemical Selenium-Catalyzed N,O-Difunctionalization of Ynamides: Access to Polysubstituted Oxazoles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03811
Abstract: A green and efficient approach for the difunctionalization of ynamides by merging the electrochemical and organoselenium-catalyzed processes is described. This strategy features mild reaction conditions, broad functional group tolerance and high atom-economy, and requires no… read more here.
Keywords: catalyzed difunctionalization; polysubstituted oxazoles; difunctionalization ynamides; electrochemical selenium ... See more keywords
Copper-Catalyzed Difunctionalization of Propargylic Carbonates through Tandem Nucleophilic Substitution/Boroprotonation.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c01080
Abstract: Highly functionalized organic molecules are in high demand, but their preparation is challenging. Copper-catalyzed transformation of alkynyl- and allenyl-containing substrates has emerged as a powerful tool to achieve this objective. Herein, an efficient copper-catalyzed difunctionalization… read more here.
Keywords: difunctionalization propargylic; tandem nucleophilic; propargylic carbonates; catalyzed difunctionalization ... See more keywords
Photoinduced Decatungstate Anion-Catalyzed 1,4-Difunctionalization of 1,3-Butadienes via C-H Activation.
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DOI: 10.1021/acs.orglett.4c01877
Abstract: This paper outlines an innovative three-component coupling strategy for the 1,4-difunctionalization of 1,3-butadiene, utilizing sodium decatungstate (NaDT) as a hydrogen atom transfer (HAT) photocatalyst. The photoinduced process efficiently generates homoallylic amino acid esters with 100%… read more here.
Keywords: decatungstate anion; photoinduced decatungstate; anion catalyzed; catalyzed difunctionalization ... See more keywords
Electrochemical iron-catalyzed difunctionalization of olefins: efficient and sustainable access to β-heteroarylated esters
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DOI: 10.1039/d5gc02319j
Abstract: Aliphatic esters are fundamental components of biologically active compounds and serve as flexible chemical intermediates in pharmaceutical synthesis. Yet, their preparation from readily accessible olefins has been fraught with challenges.... read more here.
Keywords: difunctionalization olefins; catalyzed difunctionalization; olefins efficient; iron catalyzed ... See more keywords
Palladium(0)-Catalyzed Difunctionalization of 1,3-Dienes: From Racemic to Enantioselective
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DOI: 10.1055/s-0037-1610379
Abstract: 1,3-Dienes are easily accessible chemicals that participate in a series of reactions acting on the carbon–carbon double bonds. Catalytic difunctionalization of 1,3-dienes provides a wide scope of functionalized chemicals. Pd(0) catalysts provide a diverse set… read more here.
Keywords: difunctionalization; catalyzed difunctionalization; palladium catalyzed; dienes racemic ... See more keywords