Synthesis of Carbazolylamines through Brønsted Acid‐Catalyzed Direct Electrophilic Aminations
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DOI: 10.1002/ajoc.202400197
Abstract: A Brønsted acid catalyzed direct and dual C‐H amination of carbazoles and indolocarbazoles with N‐Ts iminoquinone acetal is reported. It is characterized that the mentioned C‐H amination was determine by the selection of catalysts and… read more here.
Keywords: catalyzed direct; synthesis carbazolylamines; direct electrophilic; carbazolylamines nsted ... See more keywords
Heterogeneous Cobalt‐Catalyzed Direct N‐Formylation of Isoquinolines with CO2 and H2
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DOI: 10.1002/cctc.201601682
Abstract: Isoquinolines (IQs) are an abundant feedstock, and N‐formyl‐1,2,3,4‐tetrahydroisoquinolines (FTHIQs) are valuable fine chemicals and key intermediates. Herein, we report for the first time the Co0/ZnCl2‐catalyzed direct N‐formylation of IQs by using CO2 with H2 to… read more here.
Keywords: formylation; formylation isoquinolines; heterogeneous cobalt; cobalt catalyzed ... See more keywords
Tungsten-Catalyzed Direct N-Alkylation of Anilines with Alcohols.
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DOI: 10.1002/cssc.202002830
Abstract: The implementation of non-noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of non-noble… read more here.
Keywords: alkylation anilines; catalyzed direct; alkylation; anilines alcohols ... See more keywords
Palladium‐Catalyzed Direct C(sp3)−H Arylation of 5H‐Imidazo[2,1‐a]isoindole Scaffolds With Arylbromides
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DOI: 10.1002/ejoc.202400058
Abstract: The study of Pd(0)‐catalyzed C−H bond arylation of methyl 5H‐imidazo[2,1‐a]isoindole‐3‐carboxylates with aryl bromides is reported. This methodology gives ready access to a wide range of methyl 5H‐imidazo[2,1‐a]isoindole‐3‐carboxylates that are monoarylated at their benzylic sites. The… read more here.
Keywords: methodology; catalyzed direct; palladium catalyzed; imidazo isoindole ... See more keywords
Mechanistic study on silver-catalyzed direct amination of unactivated CH bond
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.01.006
Abstract: Abstract A systematic investigation has been conducted into the mechanism for the silver-catalyzed direct amination of unactivated C H bonds in triflamides by density functional theory (DFT). The present work is in favor of the… read more here.
Keywords: silver catalyzed; direct amination; mechanistic study; amination unactivated ... See more keywords
Cu-catalyzed direct C1−H difluoromethylation of pyrrolo[1,2-a]quinoxalines
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DOI: 10.1016/j.mcat.2021.111747
Abstract: Abstract An efficient Cu-catalyzed direct C1−H difluoromethylation of pyrrolo[1,2-a]quinoxalines with BrCF2CO2Et or BrCF2CONEt2 has been reported, providing to a series of difluoromethylated pyrrolo[1,2-a]quinoxalines with generally good yields. This approach features good compatibility with substituents, broad… read more here.
Keywords: difluoromethylation pyrrolo; pyrrolo quinoxalines; catalyzed direct; direct difluoromethylation ... See more keywords
Palladium-catalyzed direct arylation of maleimides: A simple route to bisaryl-substituted maleimides
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DOI: 10.1016/j.tet.2017.01.069
Abstract: Palladium-catalyzed direct arylation of maleimides via Heck as well as organoboron-mediated Heck-type reactions are developed. These methods offer an approach to a wide variety of biologically interesting 3,4-diarylmaleimide scaffolds from readily accessible starting materials. These… read more here.
Keywords: direct arylation; substituted maleimides; bisaryl substituted; palladium catalyzed ... See more keywords
Cu(OAc)2-catalyzed direct radical C2 arylation of quinoline N-oxide with arylamines
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DOI: 10.1016/j.tet.2017.03.009
Abstract: Abstract A Cu(OAc) 2 -catalyzed synthesis of 2-arylquinoline N -oxides with easily available arylamines is described. The main features of this reaction are mild reaction conditions, high functional-group tolerance, excellent regioselectivity, and good to excellent… read more here.
Keywords: arylation quinoline; oac catalyzed; direct radical; catalyzed direct ... See more keywords
Rhodium(III)-catalyzed direct C-7 sulfonamidation and amination of indolines with arylsulfonamides and trifluoroacetamide
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DOI: 10.1016/j.tetlet.2019.03.069
Abstract: Abstract A rhodium-catalyzed direct C–H sulfonamidation and amidation of C-7 position of indolines by simple and commercially available arylsulfonamides and trifluoroacetamide has been developed, affording a series of N -arylsulfonamides and N -aryltrifluoroacetamides in moderate… read more here.
Keywords: iii catalyzed; catalyzed direct; rhodium iii; arylsulfonamides trifluoroacetamide ... See more keywords
Iron(II)-catalyzed direct C H cyanoalkylation of 2H-indazoles and coumarins via radical C C bond cleavage
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DOI: 10.1016/j.tetlet.2019.150967
Abstract: Abstract An iron-catalyzed C-3 cyanoalkylation of 2H-indazole and coumarin derivates with cyclobutanone oxime esters has been accomplished, which proceeds efficiently in a high regioselective manner to construct diverse alkylated 2H-indazole and coumarin derivates in moderate… read more here.
Keywords: bond cleavage; iron catalyzed; cyanoalkylation; catalyzed direct ... See more keywords
MnBr2-Catalyzed Direct and Site-Selective Alkylation of Indoles and Benzo[h]quinoline.
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DOI: 10.1021/acs.orglett.0c01398
Abstract: Manganese-catalyzed regioselective C-H alkylation of indoles and benzo[h]quinoline with a variety of unactivated alkyl iodides is reported. Unlike other Mn-catalyzed C-H functionalization, this protocol does not require a Grignard reagent base and employs a simple… read more here.
Keywords: benzo quinoline; mnbr2 catalyzed; alkylation indoles; indoles benzo ... See more keywords