Heterogeneous Cobalt‐Catalyzed Direct N‐Formylation of Isoquinolines with CO2 and H2
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DOI: 10.1002/cctc.201601682
Abstract: Isoquinolines (IQs) are an abundant feedstock, and N‐formyl‐1,2,3,4‐tetrahydroisoquinolines (FTHIQs) are valuable fine chemicals and key intermediates. Herein, we report for the first time the Co0/ZnCl2‐catalyzed direct N‐formylation of IQs by using CO2 with H2 to… read more here.
Keywords: formylation; formylation isoquinolines; heterogeneous cobalt; cobalt catalyzed ... See more keywords
Tungsten-Catalyzed Direct N-Alkylation of Anilines with Alcohols.
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DOI: 10.1002/cssc.202002830
Abstract: The implementation of non-noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of non-noble… read more here.
Keywords: alkylation anilines; catalyzed direct; alkylation; anilines alcohols ... See more keywords
Mechanistic study on silver-catalyzed direct amination of unactivated CH bond
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.01.006
Abstract: Abstract A systematic investigation has been conducted into the mechanism for the silver-catalyzed direct amination of unactivated C H bonds in triflamides by density functional theory (DFT). The present work is in favor of the… read more here.
Keywords: silver catalyzed; direct amination; mechanistic study; amination unactivated ... See more keywords
Cu-catalyzed direct C1−H difluoromethylation of pyrrolo[1,2-a]quinoxalines
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DOI: 10.1016/j.mcat.2021.111747
Abstract: Abstract An efficient Cu-catalyzed direct C1−H difluoromethylation of pyrrolo[1,2-a]quinoxalines with BrCF2CO2Et or BrCF2CONEt2 has been reported, providing to a series of difluoromethylated pyrrolo[1,2-a]quinoxalines with generally good yields. This approach features good compatibility with substituents, broad… read more here.
Keywords: difluoromethylation pyrrolo; pyrrolo quinoxalines; catalyzed direct; direct difluoromethylation ... See more keywords
Palladium-catalyzed direct arylation of maleimides: A simple route to bisaryl-substituted maleimides
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.01.069
Abstract: Palladium-catalyzed direct arylation of maleimides via Heck as well as organoboron-mediated Heck-type reactions are developed. These methods offer an approach to a wide variety of biologically interesting 3,4-diarylmaleimide scaffolds from readily accessible starting materials. These… read more here.
Keywords: direct arylation; substituted maleimides; bisaryl substituted; palladium catalyzed ... See more keywords
Cu(OAc)2-catalyzed direct radical C2 arylation of quinoline N-oxide with arylamines
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DOI: 10.1016/j.tet.2017.03.009
Abstract: Abstract A Cu(OAc) 2 -catalyzed synthesis of 2-arylquinoline N -oxides with easily available arylamines is described. The main features of this reaction are mild reaction conditions, high functional-group tolerance, excellent regioselectivity, and good to excellent… read more here.
Keywords: arylation quinoline; oac catalyzed; direct radical; catalyzed direct ... See more keywords
Rhodium(III)-catalyzed direct C-7 sulfonamidation and amination of indolines with arylsulfonamides and trifluoroacetamide
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.03.069
Abstract: Abstract A rhodium-catalyzed direct C–H sulfonamidation and amidation of C-7 position of indolines by simple and commercially available arylsulfonamides and trifluoroacetamide has been developed, affording a series of N -arylsulfonamides and N -aryltrifluoroacetamides in moderate… read more here.
Keywords: iii catalyzed; catalyzed direct; rhodium iii; arylsulfonamides trifluoroacetamide ... See more keywords
Iron(II)-catalyzed direct C H cyanoalkylation of 2H-indazoles and coumarins via radical C C bond cleavage
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DOI: 10.1016/j.tetlet.2019.150967
Abstract: Abstract An iron-catalyzed C-3 cyanoalkylation of 2H-indazole and coumarin derivates with cyclobutanone oxime esters has been accomplished, which proceeds efficiently in a high regioselective manner to construct diverse alkylated 2H-indazole and coumarin derivates in moderate… read more here.
Keywords: bond cleavage; iron catalyzed; cyanoalkylation; catalyzed direct ... See more keywords
MnBr2-Catalyzed Direct and Site-Selective Alkylation of Indoles and Benzo[h]quinoline.
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DOI: 10.1021/acs.orglett.0c01398
Abstract: Manganese-catalyzed regioselective C-H alkylation of indoles and benzo[h]quinoline with a variety of unactivated alkyl iodides is reported. Unlike other Mn-catalyzed C-H functionalization, this protocol does not require a Grignard reagent base and employs a simple… read more here.
Keywords: benzo quinoline; mnbr2 catalyzed; alkylation indoles; indoles benzo ... See more keywords
Cobalt-Catalyzed Direct C-H Carbonylative Synthesis of Free (NH)-Indolo[1,2-a]quinoxalin-6(5H)-ones.
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DOI: 10.1021/acs.orglett.0c03900
Abstract: A cobalt-catalyzed direct C-H carbonylative reaction of N-(2-(1H-indol-1-yl)phenyl)picolinamides for the synthesis of (NH)-indolo[1,2-a]quinoxalin-6(5H)-one skeletons has been developed. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source and picolinamide as the traceless directing group, various free (NH)-indolo[1,2-a]quinoxalin-6(5H)-ones… read more here.
Keywords: indolo quinoxalin; free indolo; cobalt catalyzed; catalyzed direct ... See more keywords
Copper(II)-Catalyzed Direct C-H Trifluoroethylation of Heteroarenes.
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DOI: 10.1021/acs.orglett.2c00245
Abstract: Trifluoroethyl (CH2CF3) is an important functional group in many pharmaceutical and agrochemical compounds. Herein, we report an efficient method for the copper-catalyzed direct trifluoroethylation of heteroarenes. The reaction exhibited good compatibility to various substrates, and… read more here.
Keywords: trifluoroethylation heteroarenes; direct trifluoroethylation; copper catalyzed; catalyzed direct ... See more keywords