Solvent and Base in One: Tetra‐n‐butylammonium Acetate as a Multi‐Purpose Ionic Liquid Medium for Ru‐Catalyzed Directed Mono‐ and Di‐o‐C–H Arylation Reactions
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201701022
Abstract: Ru-catalyzed directed o-C–H arylation reactions of 2-phenylpyridine, N-phenylpyrazole, acetophenone N-(p-methoxyphenyl)imine, and 2-phenyloxazoline proceed in good to excellent yields with a number of functionalized aryl and heteroaryl bromides in neat Bu4NOAc at 120 °C. The acetate… read more here.
Keywords: ionic liquid; purpose ionic; catalyzed directed; arylation ... See more keywords
Rhodium-catalyzed directed C–H functionalization of 2-arylindazoles with diazotized Meldrum's acid
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2021.122009
Abstract: Abstract A rhodium-catalyzed alcohol-mediated ortho-functionalization of 2-aryl-2H-indazoles through sequential C-H activation and carbenoid insertion with diazotized Meldrum's acid was developed. Using the 2H-indazole as the directing group and alcohol as the alkyl source, a series… read more here.
Keywords: catalyzed directed; rhodium catalyzed; diazotized meldrum; functionalization ... See more keywords
Ionic liquid catalyzed Ritter reaction/Pd-catalyzed directed Ortho-arylation; facile access to diverse libraries of biaryl-amides from Aryl-nitriles
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152553
Abstract: Abstract Diverse libraries of biaryl-amides bearing N-t-butyl and N-adamantyl groups were synthesized in two steps by the Ritter reaction of aryl-nitriles, using tBuOH and AdaOH as carbocation precursors, and employing [BMIM(SO3H)][OTf] (neat or with [BMIM][PF6]… read more here.
Keywords: libraries biaryl; catalyzed directed; diverse libraries; biaryl amides ... See more keywords
Cobalt(II)-Catalyzed Directed C-H Functionalization/[3+2] Annulation of N-Arylguanidines with Alkynes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02503
Abstract: A family of N,N'-diaryl-N″-(quinolin-8-yl)guanidines were prepared by two methods, and these guanidines were subjected to Co(II)-catalyzed C-H functionalization/annulation with terminal and internal alkynes under mild conditions to afford a family of indole guanidines. Substrates with… read more here.
Keywords: cobalt catalyzed; catalyzed directed; functionalization annulation; directed functionalization ... See more keywords
Copper-Catalyzed, N-Directed Distal C(sp3)-H Functionalization toward Azepanes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03135
Abstract: We herein report a copper-catalyzed formal [5 + 2] aza-annulation of N-fluorosulfonamides and 1,3-dienes/1,3-enynes for synthesis of structurally diverse alkene/alkyne-containing azepanes. The reaction features selective functionalization of distal unactivated C(sp3)-H bonds and a broad substrate… read more here.
Keywords: distal sp3; catalyzed directed; directed distal; sp3 functionalization ... See more keywords