KIO3‐Catalyzed Domino C(sp2)−H Bond Sulfenylation and C−N Bond Oxygenation of Enaminones toward the Synthesis of 3‐Sulfenylated Chromones
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DOI: 10.1002/cctc.201601273
Abstract: With 2‐hydroxyphenyl‐functionalized enaminones and thiophenols as the starting materials, the facile synthesis of 3‐sulfenylated chromones has been realized through a KIO3‐catalyzed domino reaction of C−H sulfenylation and subsequent C−N‐cleavage‐based C−O bond formation. The reaction was… read more here.
Keywords: bond; synthesis sulfenylated; kio3 catalyzed; catalyzed domino ... See more keywords
Au-catalyzed domino process synthesis of imidazo[1,2-a]pyridines from 2-aminopyridine and N-tosylhydrazones: An efficient CN bond formation reaction
Sign Up to like & getrecommendations! Published in 2017 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2016.10.033
Abstract: Abstract A novel Au-catalyzed domino reaction for the synthesis of imidazo[1,2- a ]pyridines from 2-aminopyridine and N-tosylhydrazones has been developed using molecular oxygen. It represents a new strategy for the formation of C N bonds.… read more here.
Keywords: aminopyridine tosylhydrazones; pyridines aminopyridine; catalyzed domino; synthesis imidazo ... See more keywords
Pd-Catalyzed Domino Imidoylation/Heck/C(sp2)-H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02503
Abstract: A palladium-catalyzed domino process for the quick assembly of tricyclic-fused heterocycles starting from aryl iodides and functionalized isocyanides containing a disubstituted terminal alkene has been developed. The process is triggered by intermolecular isocyanide insertion, followed… read more here.
Keywords: sp2; domino imidoylation; catalyzed domino; fused heterocycles ... See more keywords
I2/FeCl3-Catalyzed Domino Reaction of Aurones with Enamino Esters for the Synthesis of Highly Functionalized Pyrroles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03537
Abstract: A novel and efficient I2/FeCl3-catalyzed domino reaction of aurones with enamino esters via Michael addition, iodination, intramolecular nucleophilic substitution, and spiro ring opening processes has been developed, affording a vast variety of polysubstituted pyrroles in… read more here.
Keywords: reaction; fecl3 catalyzed; domino reaction; aurones enamino ... See more keywords
Ag-Catalyzed Domino Decarboxylative Alkylation/Dearomative Annulation: Entry to Fused-Pyrido[4,3-b]Indolones.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c03556
Abstract: Here we report the development of unprecedented silver-catalyzed intramolecular annulations of N-acrolyl-2-(3-indolyl) benzimidazoles with alkyl carboxylic acids to construct complex fused-pentacyclic alkaloid scaffolds. Divergent reactivities are noticed with altered groups at C2-indole of the substrate.… read more here.
Keywords: decarboxylative alkylation; catalyzed domino; dearomative annulation;
Palladium-Catalyzed Domino Heck/Decarboxylative Cyanomethylation of Indoles and Alkenes with Cyanoacetate Salts.
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DOI: 10.1021/acs.orglett.5c01208
Abstract: A palladium-catalyzed reaction of indoles with cyanoacetate salts enables the synthesis of 2,6-disubstituted indolines via tandem dearomatization/decarboxylative cyanomethylation. Remarkably, this is the first example of indole difunctionalization at the C2 and C6 positions. Moreover, this… read more here.
Keywords: palladium catalyzed; decarboxylative cyanomethylation; domino heck; catalyzed domino ... See more keywords
Access to 1,6-Enynes via Cadmium-Catalyzed Domino A3-Coupling/Dealkylative A3-Coupling.
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DOI: 10.1021/acs.orglett.5c02765
Abstract: We herein disclose a mild and efficient cadmium-catalyzed domino reaction for accessing 1,6-enynes via a sequential A3-coupling/1,5-hydride transfer/hydrolysis/A3-coupling. This method demonstrates the compatibility of various substrates, including aliphatic, silane-substituted, aromatic, and heteroaromatic alkynes, with the… read more here.
Keywords: cadmium catalyzed; access enynes; enynes via; catalyzed domino ... See more keywords
Palladium-Catalyzed Domino Heck/Aryne Carbopalladation/C-H Functionalization: Synthesis of Heterocycle-Fused 9,10-Dihydrophenanthrenes.
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DOI: 10.1021/acs.orglett.6b03833
Abstract: A novel palladium-catalyzed domino Heck/aryne carbopalladation/C-H functionalization reaction using in situ generated arynes has been developed in which three new C-C bonds and a carbon quaternary center are formed. This methodology affords moderate to excellent… read more here.
Keywords: carbopalladation functionalization; domino heck; palladium catalyzed; heck aryne ... See more keywords
Phosphine-Catalyzed Domino β/γ-Additions of Benzofuranones with Allenoates: A Method for Unsymmetrical 3,3-Disubstituted Benzofuranones.
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DOI: 10.1021/acs.orglett.7b01482
Abstract: A phosphine-catalyzed domino process of benzofuranones with allenoates has been developed which furnishes highly functionalized unsymmetrical 3,3-disubstituted benzofuranones in synthetically useful yields. The mechanism for the transformation is a tandem β-umpolung/γ-umpolung process. read more here.
Keywords: phosphine catalyzed; unsymmetrical disubstituted; catalyzed domino; disubstituted benzofuranones ... See more keywords
Palladium-Catalyzed Domino Alkenylation/Amination/Pyridination Reactions of 2-Vinylanilines with Alkynes: Access to Cyclopentaquinolines.
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DOI: 10.1021/acs.orglett.7b03164
Abstract: A novel domino oxidative annulation of 2-vinylanilines with internal alkynes was developed to constitute a rare class of cyclopentaquinoline derivatives. This transformation encompasses four σ bonds formation, one quaternary carbon center construction, and pyridination steps… read more here.
Keywords: domino; pyridination; palladium catalyzed; alkenylation amination ... See more keywords
Copper(II)-Catalyzed Domino Synthesis of Indolo[3,2- c]quinolinones via Selective Carbonyl Migration.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03557
Abstract: A Cu(II)-catalyzed domino process involving the carbene N-H insertion, intramolecular aldol-type trapping and unprecedented ring-expansion of oxindole core through C3-selective 1,2-carbonyl migration is described for the synthesis of indolo[3,2- c]quinolinones. This tetracyclic core, having an… read more here.
Keywords: carbonyl migration; catalyzed domino; selective carbonyl; indolo quinolinones ... See more keywords