Co-Catalyzed Dual C5/C8-H Bond Functionalization of Imidazo[1,2-a]pyrazines with Disulfides and Grignard Reagents.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02937
Abstract: An efficient difunctionalization at C5/C8 of imidazo[1,2-a]pyrazines has been developed using disulfides and Grignard reagents under cheap cobalt catalysis. This one-pot, two-step, three-component transformation is performed under mild conditions; various Grignard reagents (aryl and alkyl)… read more here.
Keywords: grignard reagents; imidazo pyrazines; catalyzed dual; dual bond ... See more keywords
Rh(III)-Catalyzed Dual C-H Activation/Cascade Annulation of Benzimidates and CF3-Imidoyl Sulfoxonium Ylides for the Synthesis of Trifluoromethyl-Decorated Benzo[de][1,8]naphthyridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03666
Abstract: An efficient and straightforward approach for the synthesis of trifluoromethyl-decorated benzo[de][1,8]naphthyridines has been achieved via the Rh(III)-catalyzed dual C-H activation and cascade annulation of benzimidates and CF3-imidoyl sulfoxonium ylides. The novel transformation involves the formation… read more here.
Keywords: synthesis trifluoromethyl; decorated benzo; catalyzed dual; benzo naphthyridines ... See more keywords
Phosphine-Catalyzed Dual Umpolung Domino Michael Reaction: Facile Synthesis of Hydroindole- and Hydrobenzofuran-2-Carboxylates
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DOI: 10.1021/acscatal.8b01011
Abstract: A highly atom-economical, chemoselective, and stereoselective Lewis base (LB)-catalyzed dual umpolung domino Michael reaction between cyclohexadienones and alkynyl esters has been developed. PPh3, as a LB catalyst, afforded either the hydroindole-2-carboxylates or hydrobenzofuran-2-carboxylates 3 as… read more here.
Keywords: umpolung domino; hydrobenzofuran carboxylates; domino michael; catalyzed dual ... See more keywords
CuSO4-Catalyzed dual annulation to synthesize O, S or N-containing tetracyclic heteroacenes.
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DOI: 10.1039/d0cc01172j
Abstract: In this work, CuSO4 is utilized as a practical redox catalyst for tandem dual annulation in the synthesis of indole-fused tetracyclic heteroacenes, which are important skeletons in both medicinal chemistry and materials chemistry. The preparation… read more here.
Keywords: cuso4 catalyzed; chemistry; tetracyclic heteroacenes; dual annulation ... See more keywords