Zn-ProPhenol Catalyzed Enantio- and Diastereoselective Direct Vinylogous Mannich Reactions between α,β- and β,γ-Butenolides and Aldimines.
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DOI: 10.1021/jacs.7b11361
Abstract: We report a Zn-ProPhenol catalyzed reaction between butenolides and imines to obtain tetrasubstituted vinylogous Mannich products in good yield and diastereoselectivity with excellent enantioselectivity (97 to >99.5% ee). Notably, both α,β- and β,γ-butenolides can be… read more here.
Keywords: catalyzed enantio; enantio diastereoselective; vinylogous mannich; diastereoselective direct ... See more keywords