A Cobalt-Catalyzed Enantioconvergent Radical Negishi C(sp3)–C(sp2) Cross-Coupling with Chiral Multidentate N,N,P-Ligand
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DOI: 10.1021/acs.organomet.1c00190
Abstract: A cobalt-catalyzed enantioconvergent radical Negishi C(sp)−C(sp) cross-coupling of racemic benzyl chlorides with arylzinc reagents has been developed in good yield with moderate enantioselectivities. This strategy provides an expedient access toward a range of enantioenriched 1,1-diarylmethanes.… read more here.
Keywords: enantioconvergent cross; cross coupling; cross; catalyzed enantioconvergent ... See more keywords
Diverse Synthesis of Chiral Trifluoromethylated Alkanes via Nickel-Catalyzed Enantioconvergent Reductive Hydroalkylation of Unactivated Olefins.
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DOI: 10.1021/acs.orglett.2c00148
Abstract: Here, we report a nickel-catalyzed enantioconvergent hydroalkylation of olefins with trifluoromethyl-containing α-alkyl halides for the synthesis of enantioenriched trifluoromethylated alkanes. This reaction employs readily available and bench-stable alkenes as alkyl coupling partners, featuring mild conditions,… read more here.
Keywords: diverse synthesis; hydroalkylation; nickel catalyzed; trifluoromethylated alkanes ... See more keywords
Photoinduced, Copper-Catalyzed Enantioconvergent Alkylations of Anilines by Racemic Tertiary Electrophiles: Synthesis and Mechanism.
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DOI: 10.1021/jacs.1c12749
Abstract: Transition-metal catalysis of substitution reactions of alkyl electrophiles by nitrogen nucleophiles is beginning to emerge as a powerful strategy for synthesizing higher-order amines, as well as controlling their stereochemistry. Herein, we report that a readily… read more here.
Keywords: copper; racemic tertiary; mechanism; catalyzed enantioconvergent ... See more keywords
Cobalt-Catalyzed Enantioconvergent Hydrogenation of Minimally Functionalized Isomeric Olefins.
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DOI: 10.1021/jacs.2c08525
Abstract: Investigation on asymmetric hydrogenation of olefins is of great importance in both pharmaceutical molecule synthesis and chemical industry due to the high demand for enantiopure compounds. The established methods often require geometrically pure olefins. The… read more here.
Keywords: cobalt catalyzed; minimally functionalized; hydrogenation; hydrogenation minimally ... See more keywords
Pd(ii)-Catalyzed enantioconvergent twofold C–H annulation to access atropisomeric aldehydes: a platform for diversity-oriented-synthesis
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DOI: 10.1039/d1qo00183c
Abstract: The first Pd(ii)-catalyzed atroposelective dual C–H annulative strategy for diverse synthesis of functionalized axially chiral biaryls was developed. read more here.
Keywords: access atropisomeric; synthesis; annulation access; twofold annulation ... See more keywords