Lipase-catalyzed enantioselective transesterification of prochiral 1-((1,3-dihydroxypropan-2-yloxy)methyl)-5,6,7,8-tetrahydroquinazoline-2,4(1H,3H)-dione in ionic liquids.
Sign Up to like & getrecommendations! Published in 2018 at "Chirality"
DOI: 10.1002/chir.22787
Abstract: The application of ionic liquids as solvents for transesterification of prochiral pirymidine acyclonucleoside using lipase (EC 3.1.1.3) Amano PS from Burkholderia cepacia (BCL) is reported. The effect of using medium reaction, acyl group donor, and… read more here.
Keywords: lipase catalyzed; bmim pf6; catalyzed enantioselective; transesterification prochiral ... See more keywords
Rational enhancement of enzyme-catalyzed enantioselective reaction by construction of recombinant enzymes based on additive strategy
Sign Up to like & getrecommendations! Published in 2019 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-019-02170-1
Abstract: A rational enhancement of kinetic resolution process for producing (S)-N-(2-ethyl-6-methylphenyl) alanine from racemic methyl ester using lipase B from Candida antarctica (CalB) was investigated. With the benefit results that lipase CalB-catalyzed reactions can be effectively… read more here.
Keywords: rational enhancement; catalyzed enantioselective; reaction; enzyme catalyzed ... See more keywords
Copper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights
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DOI: 10.1016/j.mcat.2020.111067
Abstract: Abstract We report a novel and efficient Cu-catalyzed direct asymmetric amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives,… read more here.
Keywords: direct amination; amination dicarbonyl; catalyzed enantioselective; enantioselective direct ... See more keywords
Brønsted acid catalyzed enantioselective pericyclic reactions
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.02.059
Abstract: Abstract Pericyclic reactions can be challenging processes to render asymmetric, due to the concerted and non-polar nature of the transition states. Several examples have been reported in which a suitable catalyst binds to a heteroatom-containing… read more here.
Keywords: nsted acid; catalyzed enantioselective; acid catalyzed; pericyclic reactions ... See more keywords
Molybdenum-Catalyzed Enantioselective Synthesis of Planar-Chiral (η5-Phosphacyclopentadienyl)manganese(I) Complexes and Application in Asymmetric Catalysis
Sign Up to like & getrecommendations! Published in 2017 at "Organometallics"
DOI: 10.1021/acs.organomet.7b00704
Abstract: Enantioselective desymmetrization of Cs-symmetric (η5-2,5-dialkenylphospholyl)(allyldiphenylphosphine)manganese(I) dicarbonyl complexes 1 was realized by molybdenum-catalyzed asymmetric ring-closing metathesis (ARCM), and the corresponding bridged planar-chiral phosphacymantrene derivatives 2 were obtained in good yields with excellent enantioselectivity. The enantioselectivity of… read more here.
Keywords: enantioselectivity; molybdenum catalyzed; catalyzed enantioselective; planar chiral ... See more keywords
Brønsted Acid Catalyzed Enantioselective Assemblyof Spirochroman-3,3-oxindoles
Sign Up to like & getrecommendations! Published in 2020 at "Organic Letters"
DOI: 10.1021/acs.orglett.0c00587.s001
Abstract: An enantioselective cyclization of diazoindolinones with o-hydroxymethyl chalcones has been established by a cooperative dirhodium complex and chiral phosphonic acid catalysis under mild conditions. This reaction is the first example of catalytic asymmetric intramolecular Michael-type… read more here.
Keywords: spirochroman oxindoles; nsted acid; spirochroman; catalyzed enantioselective ... See more keywords
NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02832
Abstract: The unprecedented enantioselective NHC-catalyzed [3 + 3] annulation of α-bromoenals with amidines via a dual C-N bond formation is described. The protocol allows a rapid preparation of 5,6-dihydropyrimidinones in acceptable yields with good enantioselectivities. read more here.
Keywords: annulation; construct dihydropyrimidin; nhc catalyzed; catalyzed enantioselective ... See more keywords
Ni-Catalyzed Enantioselective Allylic Alkylation of H-Phosphinates.
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DOI: 10.1021/acs.orglett.1c02986
Abstract: The asymmetric synthesis of P-stereogenic phosphinates through allylic alkylation of H-phosphinates has been developed. With H-phosphinates and allylic acetates as the starting materials, a variety of allylic P-chiral phosphinates were accessed in high enantioselectivities of… read more here.
Keywords: alkylation phosphinates; enantioselective allylic; catalyzed enantioselective; allylic alkylation ... See more keywords
Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03596
Abstract: The copper-catalyzed enantioselective C-H arylation between 2-arylindoles and hypervalent iodine reagents has been successfully developed, which provides a convenient and economical route to the highly atroposelective synthesis of axially chiral indole derivatives with a 2-aryl… read more here.
Keywords: hypervalent iodine; enantioselective arylation; arylation arylindoles; catalyzed enantioselective ... See more keywords
Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04073
Abstract: The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH… read more here.
Keywords: hydroboration vinylarenes; nickel catalyzed; enantioselective hydroboration; catalyzed enantioselective ... See more keywords
Copper-Catalyzed Enantioselective 1,4-Protosilylation of Alkynyl-substituted Enones to Synthesize the Highly Diastereomeric Chiral Homoallenylsilanes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00739
Abstract: A copper-catalyzed 1,4-protosilylation of α-alkynyl-enones to form the functionalized chiral homoallenylsilanes was developed. In the presence of a chiral monopyridine oxazoline ligand, a variety of trisubstituted allene derivatives bearing a contiguous stereogenic center and axis… read more here.
Keywords: copper catalyzed; catalyzed enantioselective; chiral homoallenylsilanes; protosilylation alkynyl ... See more keywords