Palladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation.
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DOI: 10.1021/acs.orglett.1c03970
Abstract: Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles has been accomplished using a readily available arene at moderate temperature. The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications… read more here.
Keywords: arylation; arylation indoles; catalyzed fold; palladium catalyzed ... See more keywords
Palladium-Catalyzed 4-Fold Domino Reaction for the Synthesis of a Polymeric Double Switch.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00553
Abstract: A palladium-catalyzed 4-fold domino reaction consisting of two carbopalladation reactions and two C-H activation reactions, followed by the introduction of an acrylate moiety, led to the tetra-substituted helical alkene A2, using the dialkyne A3 as… read more here.
Keywords: palladium catalyzed; catalyzed fold; fold domino; domino reaction ... See more keywords