Synthesis of N,N'‐Bisindoles via Gold‐Catalyzed Formal (4+1) Cycloaddition
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500193
Abstract: Indole‐based heterocycles are commonly found in natural products and pharmaceuticals, so the synthesis of such heterocycles has become an important research area. In spite of the rapid development of this research area, the synthesis of… read more here.
Keywords: bisindoles via; catalyzed formal; gold catalyzed; synthesis ... See more keywords
Benzenediazonium Tetrafluoroborate‐Catalyzed Formal [3 + 3] Cyclization of 4‐Hydroxycoumarins With Propargylicalcohols
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DOI: 10.1002/jhet.4912
Abstract: A formal [3 + 3] cycloaddition of 4‐hydroxycoumarins with propargylicalcohols was established under mild conditions. This strategy utilizes diazonium tetrafluoroborate as the Lewis acid catalyst and provides a practical approach for delivering pyranocoumarin derivatives in moderate to… read more here.
Keywords: hydroxycoumarins propargylicalcohols; catalyzed formal; formal cyclization; benzenediazonium tetrafluoroborate ... See more keywords
Unusual Lewis-acid catalyzed formal (3+3)-cycloaddition of azomethine imines and nitrones to N-vinylpyrroles
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DOI: 10.1016/j.tet.2016.12.034
Abstract: Abstract The addition of Lewis acids change the reaction mechanism of the cycloaddition of N-vinylpyrroles with azomethine imine and C,N-diarylnitrones. The formal (3+3)-cycloaddition is observed instead of (3+2)-dipolar cycloaddition, which take place in the absence… read more here.
Keywords: cycloaddition; lewis acid; unusual lewis; formal cycloaddition ... See more keywords
Copper-catalyzed formal propargylic [3 + 2] cycloaddition for stereoselective construction of (E)-β-pyrazolylacrylates
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DOI: 10.1016/j.tetlet.2019.151409
Abstract: Abstract A copper-catalyzed formal propargylic [3 + 2] cycloaddition between propargylic acetates and 3-(2-tosylhydrazono)propanoates for the synthesis of (E)-β-substituted-β-pyrazolylacrylates has been realized. The reaction showed broad substrate scope and excellent stereoselectivities, thus leading to a variety of… read more here.
Keywords: formal propargylic; propargylic cycloaddition; catalyzed formal; cycloaddition stereoselective ... See more keywords
Allenes and Derivatives in Gold(I)- and Platinum(II)-Catalyzed Formal Cycloadditions
Sign Up to like & getrecommendations! Published in 2019 at "Accounts of Chemical Research"
DOI: 10.1021/acs.accounts.8b00567
Abstract: Conspectus Cycloaddition reactions, by involving the formation of at least two bonds and one cycle in a single operation, represent one of the more practical ways to assemble carbo- and heterocyclic structures from simple acyclic… read more here.
Keywords: platinum; catalyzed formal; formal cycloadditions; gold ... See more keywords
Indium-Catalyzed Formal Carbon-Halogen Bond Insertion: Synthesis of α-Halo-α,α-disubstituted Esters from Benzylic Halides and Diazo Esters.
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DOI: 10.1021/acs.orglett.2c00343
Abstract: One-carbon-unit insertion into carbon-halogen (C-X) bonds accompanied by the formation of a new C-X bond and carbon-chain elongation is a powerful synthetic method of complex organohalides. Herein, we developed an indium trihalide catalyzed formal insertion… read more here.
Keywords: carbon; catalyzed formal; insertion; carbon halogen ... See more keywords
Regio- and Chemoselective Copper-Catalyzed Formal [2+2+2] Cycloaddition of Primary Amines with Arylacetylenes to 2,4,5-Trisubstituted Pyridines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02606
Abstract: Disclosed herein is an efficient strategy for the synthesis of 2,4,5-trisubstituted pyridines via CuI/NBS-catalyzed formal intermolecular [2+2+2] cycloaddition of easily available primary amines and nonactivated terminal alkynes. Moreover, this given reaction features a new mode… read more here.
Keywords: catalyzed formal; regio chemoselective; chemoselective copper; trisubstituted pyridines ... See more keywords
Gold-Catalyzed Formal [3 + 2] Cycloaddition of Ynamides with 4,5-Dihydro-1,2,4-oxadiazoles: Synthesis of Functionalized 4-Aminoimidazoles.
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DOI: 10.1021/acs.orglett.7b01469
Abstract: A gold-catalyzed formal [3 + 2] cycloaddition of ynamides with 4,5-dihydro-1,2,4-oxadiazoles has been developed. The reaction provides a concise and regioselective access to highly functionalized 4-aminoimidazoles likely via the formation of an α-imino gold carbene… read more here.
Keywords: dihydro oxadiazoles; ynamides dihydro; formal cycloaddition; catalyzed formal ... See more keywords
DFT Studies on the Mechanism of the Iridium-Catalyzed Formal [4 + 1] Cycloaddition of Biphenylene with Alkenes
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DOI: 10.1021/acsomega.7b00403
Abstract: Recently, we reported an Ir-catalyzed formal [4 + 1] cycloaddition of biphenylenes with alkenes, which gave 9,9-disubstituted fluorenes in moderate to excellent yields. We proposed a reaction mechanism that involved the intermolecular insertion of alkenes,… read more here.
Keywords: cycloaddition; dft studies; formal cycloaddition; catalyzed formal ... See more keywords
Copper-Catalyzed Formal Dehydration Polymerization of Propargylic Alcohols via Cumulene Intermediates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00599
Abstract: Here we report a copper-catalyzed formal dehydration polymerization of propargylic alcohols. Copper catalysis allows for efficient in situ generation of [n]cumulenes (n = 3, 5) by a soft deprotonation/β-elimination pathway and subsequent polymerization via organocopper… read more here.
Keywords: copper catalyzed; polymerization propargylic; dehydration polymerization; polymerization ... See more keywords
Cerium-Catalyzed Formal Cycloaddition of Cycloalkanols with Alkenes through Dual Photoexcitation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b08781
Abstract: We describe a synergistic utilization of cerium photocatalysis and photoinduced electron transfer catalysis that enables an atom- and step-economical ring expansion of readily available cycloalkanols. This operationally simple protocol provides rapid access to privileged and… read more here.
Keywords: cycloaddition cycloalkanols; cerium; formal cycloaddition; cerium catalyzed ... See more keywords