Copper(I)‐Catalyzed Four‐Component Interrupted Click/Amination: Efficient Synthesis of Fully Substituted 5‐Amino‐1,2,3‐Triazoles
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DOI: 10.1002/ajoc.70253
Abstract: A copper(I)‐catalyzed four‐component interrupted click/amination cascade reaction for the efficient synthesis of various 5‐amino‐1,2,3‐triazoles has been developed. The key step in this reaction is the interception of the in situ‐formed cuprate‐triazole intermediate with O ‐benzoylhydroxylamine.… read more here.
Keywords: catalyzed four; component; component interrupted; copper catalyzed ... See more keywords
Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions
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DOI: 10.1038/s41467-024-49870-1
Abstract: 1,2-Difunctionalization of alkynes offers a straightforward approach to access polysubstituted alkenes. However, simultaneous multi-component cascade transformations including difunctionalization of two alkynes with both syn- and anti-selectivity in one catalyst system is undeveloped and proves to… read more here.
Keywords: catalyzed four; access polysubstituted; access; four component ... See more keywords
A copper-catalyzed four-component reaction of arylcyclopropanes, nitriles, carboxylic acids and N-fluorobenzenesulfonimide: facile synthesis of imide derivatives
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DOI: 10.1039/d2sc04913a
Abstract: An unprecedented copper-catalyzed four-component reaction of arylcyclopropanes, nitriles, carboxylic acids and N-fluorobenzenesulfonimide (NFSI) has been successfully developed, which represents the first example of a four-component reaction of non-donor–acceptor cyclopropanes. A wide range of imide derivatives… read more here.
Keywords: four component; reaction arylcyclopropanes; component reaction; catalyzed four ... See more keywords
Palladium-Catalyzed Four-Component Domino Sulfonylation and Carbonylation of 1,3-Enynes at Room Temperature
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DOI: 10.1039/d4qo01299b
Abstract: Multicomponent reactions (MCRs) provide an efficient and straightforward approach to access valuable complex molecules bearing diverse functional groups with excellent chemoselectivity and regioselectivty. In this work, a novel palladium-catalyzed four-component... read more here.
Keywords: catalyzed four; palladium catalyzed; four component; component domino ... See more keywords
Copper-catalyzed four-component borocarbonylative allylation of vinyl arenes to β-boryl enones.
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DOI: 10.1039/d5cc05832e
Abstract: We present here a novel copper-catalyzed four-component borocarbonylative allylation of aryl olefins. Utilizing carbon monoxide as the carbonyl source under mild reaction conditions, this protocol employs readily available aryl olefins, bis(pinacolato)diboron, and allylic phosphates as… read more here.
Keywords: borocarbonylative allylation; catalyzed four; copper catalyzed; component borocarbonylative ... See more keywords