Copper-Catalyzed Highly Selective Hydrosilylation of Silyl or Boryl Alkene: A Method for Preparing Chiral Geminated Disilyl and Borylsilyl Reagents.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00858
Abstract: The copper-catalyzed highly selective hydrosilylation of silyl or boryl alkene has been developed. This chemistry could afford a practical method for preparing chiral geminated disilyl and borylsilyl reagents, which are useful organosilanes and versatile synthons… read more here.
Keywords: chemistry; selective hydrosilylation; hydrosilylation silyl; copper catalyzed ... See more keywords
Rhodium-Catalyzed Highly Enantio- and Diastereoselective Alkenylation of β,γ-Unsaturated Butenolides via Dynamic Kinetic Resolution.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03551
Abstract: A rhodium-catalyzed highly enantio- and diastereoselective alkenylation of β,γ-unsaturated butenolides is reported. The use of a chiral diene ligand, (S,S)-Ph-bod, enables the facile synthesis of chiral butyrolactones in high yields with extremely high enantioselectivities (>99%… read more here.
Keywords: alkenylation; enantio diastereoselective; rhodium catalyzed; unsaturated butenolides ... See more keywords
Cu(I)-Catalyzed Highly Regioselective C-H Amidation of Quinoline N-Oxides with Dioxazolones.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c03118
Abstract: A Cu(I)-catalyzed highly regioselective synthesis of 2-acetamidequinoline N-oxides using dioxazolones with quinoline N-oxides has been reported. The reaction possesses mild reaction conditions and excellent functional group compatibility. Furthermore, the addition of hydrochloric acid promotes the… read more here.
Keywords: regioselective amidation; catalyzed highly; amidation quinoline; highly regioselective ... See more keywords
Chiral Imidodiphosphoric Acid-Catalyzed Highly Diastereo- and Enantioselective Synthesis of Poly-Substituted 3,4-Dihydro-2 H-pyrans: [4 + 2] Cycloadditions of β,γ-Unsaturated α-Ketoesters and 3-Vinylindoles.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01675
Abstract: Imidodiphosphoric acids were employed to catalyze inverse-electron-demand hetero-Diels-Alder reaction of β,γ-unsaturated α-ketoesters and 3-vinylindoles. A series of optically active 3,4-dihydro-2 H-pyran derivatives with three contiguous stereogenic centers was synthesized in excellent yields (70-99%), diastereoselectivities (>20:1),… read more here.
Keywords: ketoesters vinylindoles; imidodiphosphoric acid; catalyzed highly; chiral imidodiphosphoric ... See more keywords
Gold(I)-Catalyzed Highly Enantioselective [4 + 2]-Annulations of Cyclopentadienes with Nitrosoarenes via Nitroso-Povarov versus Oxidative Nitroso-Povarov Reactions
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c01293
Abstract: This work reports gold-catalyzed highly enantioselective nitroso-Povarov reactions between cyclopentadienes and nitrosoarenes in cold dichloroethane, in which nitrosoarenes serve as 4π-electron don... read more here.
Keywords: catalyzed highly; povarov; povarov reactions; nitroso povarov ... See more keywords
Iridium-Catalyzed Highly Efficient and Site-Selective Deoxygenation of Alcohols
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.8b02495
Abstract: An iridium-catalyzed, highly efficient, and site-selective deoxygenation of primary, secondary, and tertiary alcohols has been realized, under the assistance of a 4-(N-substituted amino)aryl directing group. Only the hydroxyl adjacent to the directing group can be… read more here.
Keywords: catalyzed highly; site selective; iridium catalyzed; deoxygenation ... See more keywords
Challenging Task of Ni-Catalyzed Highly Regio-/Enantioselective Semihydrogenation of Racemic Tetrasubstituted Allenes via a Kinetic Resolution Process.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c12597
Abstract: The first earth-abundant transition metal Ni-catalyzed highly regio- and enantioselective semihydrogenation of racemic tetrasubstituted allenes via a kinetic resolution process as a challenging task was well established. This protocol furnishes expedient access to a diversity… read more here.
Keywords: regio enantioselective; semihydrogenation; catalyzed highly; highly regio ... See more keywords
Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22498-1
Abstract: Pyrazolones are a vital class of heterocycles possessing various biological properties and much attention is paid to the diversified synthesis of enantiopure pyrazolone derivatives. We describe here the development of diphenylphosphinoalkanoic acid based chiral bisphosphine… read more here.
Keywords: catalyzed highly; palladium catalyzed; stretchable chiral; chiral pockets ... See more keywords
Copper-catalyzed highly selective approach to 2-boroallylic silanes from allenylsilanes
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00135e
Abstract: A highly chemo- and regioselective copper-catalyzed borylcupration of 1,2-allenylsilanes affords 2-borylallylsilanes by applying the ligand effect. Many synthetically attractive functional groups are well tolerated. As demonstrated, such 2-borylallylsilanes are very useful dimetallic reagents in organic… read more here.
Keywords: highly selective; catalyzed highly; selective approach; boroallylic silanes ... See more keywords
Cobalt-catalyzed highly diastereoselective [3 + 2] carboannulation reactions: facile access to substituted indane derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc05245d
Abstract: Efficient oxidative [3 + 2] annulation reaction involving aryl hydrazones and heterobicyclic alkenes has been realized with inexpensive and earth-abundant cobalt salts under aerobic conditions. The reaction proceeds via directing-group-assisted C-H activation and exo-selective migratory… read more here.
Keywords: cobalt catalyzed; diastereoselective carboannulation; carboannulation reactions; highly diastereoselective ... See more keywords
A photo- and cobalt-catalyzed highly selective and divergent hydrofunctionalization of 1,3-dienes with phenols
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d5sc00438a
Abstract: An applicable cobalt-hydride-mediated selective, divergent hydroetherification and sequential hydroetherification/hydroarylation of 1,3-dienes with simple phenol feedstocks under a photoredox and cobalt catalytic system have been developed. A variety of allyl aryl ethers and value-added chroman derivatives… read more here.
Keywords: divergent; selective divergent; hydrofunctionalization; cobalt catalyzed ... See more keywords